Kurs & Likviditet
Kalender
2024-11-12 | Kvartalsrapport 2024-Q3 |
2024-07-25 | Kvartalsrapport 2024-Q2 |
2024-04-25 | Kvartalsrapport 2024-Q1 |
2024-04-11 | Årsstämma 2024 |
2024-02-22 | Halvårsutdelning AZN 20.65 |
2024-02-08 | Bokslutskommuniké 2023 |
2023-11-09 | Kvartalsrapport 2023-Q3 |
2023-08-10 | Halvårsutdelning AZN 9.64 |
2023-07-28 | Kvartalsrapport 2023-Q2 |
2023-04-27 | Årsstämma 2023 |
2023-04-27 | Kvartalsrapport 2023-Q1 |
2023-02-23 | Halvårsutdelning AZN 20.69 |
2023-02-09 | Bokslutskommuniké 2022 |
2022-11-10 | Kvartalsrapport 2022-Q3 |
2022-08-11 | Halvårsutdelning AZN 9.49 |
2022-07-29 | Kvartalsrapport 2022-Q2 |
2022-04-29 | Kvartalsrapport 2022-Q1 |
2022-04-29 | Årsstämma 2022 |
2022-02-24 | Halvårsutdelning AZN 18 |
2022-02-10 | Bokslutskommuniké 2021 |
2021-11-12 | Kvartalsrapport 2021-Q3 |
2021-08-12 | Halvårsutdelning AZN 7.72 |
2021-07-29 | Kvartalsrapport 2021-Q2 |
2021-05-11 | Årsstämma 2021 |
2021-04-30 | Kvartalsrapport 2021-Q1 |
2021-02-25 | Halvårsutdelning AZN 15.76 |
2021-02-11 | Bokslutskommuniké 2020 |
2020-11-05 | Kvartalsrapport 2020-Q3 |
2020-08-13 | Halvårsutdelning AZN 7.87 |
2020-07-30 | Kvartalsrapport 2020-Q2 |
2020-04-29 | Årsstämma 2020 |
2020-04-29 | Kvartalsrapport 2020-Q1 |
2020-02-27 | Halvårsutdelning AZN 18.32 |
2020-02-14 | Bokslutskommuniké 2019 |
2019-10-24 | Kvartalsrapport 2019-Q3 |
2019-08-08 | Halvårsutdelning AZN 8.49 |
2019-07-25 | Kvartalsrapport 2019-Q2 |
2019-04-26 | Kvartalsrapport 2019-Q1 |
2019-04-26 | Årsstämma 2019 |
2019-02-28 | Halvårsutdelning AZN 17.46 |
2019-02-14 | Bokslutskommuniké 2018 |
2018-11-08 | Kvartalsrapport 2018-Q3 |
2018-08-09 | Halvårsutdelning AZN 7.92 |
2018-07-26 | Kvartalsrapport 2018-Q2 |
2018-05-18 | Kvartalsrapport 2018-Q1 |
2018-05-18 | Årsstämma 2018 |
2018-02-15 | Halvårsutdelning AZN 14.97 |
2018-02-02 | Bokslutskommuniké 2017 |
2017-11-09 | Kvartalsrapport 2017-Q3 |
2017-08-10 | Halvårsutdelning AZN 7.4 |
2017-07-27 | Kvartalsrapport 2017-Q2 |
2017-04-27 | Årsstämma 2017 |
2017-04-27 | Kvartalsrapport 2017-Q1 |
2017-02-16 | Halvårsutdelning AZN 16.57 |
2017-02-02 | Bokslutskommuniké 2016 |
2016-11-10 | Kvartalsrapport 2016-Q3 |
2016-08-11 | Halvårsutdelning AZN 7.81 |
2016-07-28 | Kvartalsrapport 2016-Q2 |
2016-04-29 | Kvartalsrapport 2016-Q1 |
2016-04-29 | Årsstämma 2016 |
2016-02-18 | Halvårsutdelning AZN 16.26 |
2016-02-04 | Bokslutskommuniké 2015 |
2015-11-05 | Kvartalsrapport 2015-Q3 |
2015-08-13 | Halvårsutdelning AZN 7.71 |
2015-07-30 | Kvartalsrapport 2015-Q2 |
2015-04-24 | Kvartalsrapport 2015-Q1 |
2015-04-24 | Årsstämma 2015 |
2015-02-19 | Halvårsutdelning AZN 15.62 |
2015-02-05 | Bokslutskommuniké 2014 |
2014-11-06 | Kvartalsrapport 2014-Q3 |
2014-08-13 | Halvårsutdelning AZN 6.2 |
2014-07-31 | Kvartalsrapport 2014-Q2 |
2014-04-24 | Kvartalsrapport 2014-Q1 |
2014-04-24 | Årsstämma 2014 |
2014-02-19 | Halvårsutdelning AZN 12.41 |
2014-02-06 | Bokslutskommuniké 2013 |
2013-10-31 | Kvartalsrapport 2013-Q3 |
2013-08-14 | Halvårsutdelning AZN 5.92 |
2013-08-01 | Kvartalsrapport 2013-Q2 |
2013-08-01 | Analytiker möte 2013 |
2013-04-25 | Kvartalsrapport 2013-Q1 |
2013-04-25 | Årsstämma 2013 |
2013-02-13 | Halvårsutdelning AZN 12.08 |
2013-01-31 | Bokslutskommuniké 2012 |
2012-10-25 | Kvartalsrapport 2012-Q3 |
2012-10-25 | Analytiker möte 2012 |
2012-08-08 | Halvårsutdelning AZN 6.26 |
2012-07-26 | Kvartalsrapport 2012-Q2 |
2012-04-26 | Kvartalsrapport 2012-Q1 |
2012-04-26 | Årsstämma 2012 |
2012-02-15 | Halvårsutdelning AZN 13.21 |
2012-02-02 | Bokslutskommuniké 2011 |
2011-10-27 | Kvartalsrapport 2011-Q3 |
2011-08-03 | Halvårsutdelning AZN 5.33 |
2011-07-28 | Kvartalsrapport 2011-Q2 |
2011-04-28 | Årsstämma 2011 |
2011-04-28 | Kvartalsrapport 2011-Q1 |
2011-02-02 | Halvårsutdelning AZN 11.99 |
2011-01-27 | Bokslutskommuniké 2010 |
2010-10-28 | Kvartalsrapport 2010-Q3 |
2010-08-04 | Halvårsutdelning AZN 5.12 |
2010-07-29 | Kvartalsrapport 2010-Q2 |
2010-04-29 | Kvartalsrapport 2010-Q1 |
2010-02-03 | Halvårsutdelning AZN 12.43 |
2010-01-28 | Bokslutskommuniké 2009 |
2009-10-29 | Kvartalsrapport 2009-Q3 |
2009-08-05 | Halvårsutdelning AZN 4.41 |
2009-07-30 | Kvartalsrapport 2009-Q2 |
2009-04-30 | Kvartalsrapport 2009-Q1 |
2009-04-30 | Årsstämma 1 |
2009-02-04 | Halvårsutdelning AZN 12.02 |
2008-08-06 | Halvårsutdelning AZN 3.34 |
2008-02-06 | Halvårsutdelning AZN 8.61 |
2007-08-08 | Halvårsutdelning AZN 3.49 |
2007-02-07 | Halvårsutdelning AZN 8.6 |
2006-08-09 | Halvårsutdelning AZN 3.6 |
2006-02-08 | Halvårsutdelning AZN 7.02 |
2005-08-10 | Halvårsutdelning AZN 2.99 |
2005-02-09 | Halvårsutdelning AZN 4.497 |
2004-08-11 | Halvårsutdelning AZN 2.2 |
2004-02-18 | Halvårsutdelning AZN 3.91 |
2003-08-20 | Halvårsutdelning AZN 2.07 |
2003-02-19 | Halvårsutdelning AZN 3.99 |
2002-08-21 | Halvårsutdelning AZN 2.21 |
2002-02-20 | Halvårsutdelning AZN 5.01 |
2001-08-22 | Halvårsutdelning AZN 2.44 |
2001-02-21 | Halvårsutdelning AZN 4.49 |
2000-09-04 | Halvårsutdelning AZN 2.1 |
2000-03-08 | Halvårsutdelning AZN 4.01 |
1999-09-06 | Halvårsutdelning AZN 1.89 |
1999-04-01 | Split AZN 1:0.5045 |
1997-05-26 | Split AZN 1:2 |
1993-06-14 | Split AZN 1:5 |
1987-06-04 | Split AZN 1:2 |
Beskrivning
Land | Storbritannien |
---|---|
Lista | Large Cap Stockholm |
Sektor | Hälsovård |
Industri | Läkemedel & Handel |
AstraZeneca has closed a global development and commercialisation agreement (https://www.astrazeneca.com/content/astraz/media-centre/press-releases/2021/astrazeneca-ionis-to-collaborate-on-eplontersen.html) with Ionis Pharmaceuticals, Inc. (Ionis) for eplontersen, formerly known as IONIS-TTR-L\RX.\
The companies will jointly develop and commercialise eplontersen in the US, while AstraZeneca will develop and commercialise it in the rest of the world, except in Latin America.
Financial considerations
Under the terms of the agreement, the upfront payment from AstraZeneca to Ionis is $200m. AstraZeneca will make additional conditional payments of up to $485m following regulatory approvals. It will also pay up to $2.9bn of sales-related milestones based on sales thresholds between $500m and $6bn, plus royalties in the range of low double-digit to mid-twenties percentage depending on the region. The collaboration includes territory-specific development, commercial and medical affairs cost-sharing provisions.
The transaction will be funded with cash and is expected to be neutral to Core earnings in 2021. It will be accounted for as an intangible asset acquisition, recognised initially at the upfront amount, with any potential future milestone payments capitalised into the intangible asset as they are recognised.
Ionis will continue to manufacture and supply eplontersen for the existing clinical studies and process qualification. AstraZeneca will be responsible for commercial supply, with transition timing to be agreed by both parties. AstraZeneca will book all sales generated under the agreement.
The transaction does not impact AstraZeneca's financial guidance for 2021.
Notes
Eplontersen
Eplontersen is a ligand-conjugated antisense (LICA) investigational medicine designed to reduce the production of transthyretin, or TTR protein, to treat all types of TTR amyloidosis (ATTR), a systemic, progressive and fatal disease.
TTR Amyloidosis (ATTR)
Cardiomyopathy and polyneuropathy due to ATTR are caused by aging or genetic mutations resulting in misfolded TTR protein and accumulation as amyloid fibrils in the cardiac myocardium and peripheral nerves, respectively. In patients with ATTR, both the mutant and wild type TTR protein builds up as fibrils in tissues, such as the peripheral nerves, heart, gastrointestinal system, eyes, kidneys, central nervous system, thyroid and bone marrow. The presence of TTR fibrils interferes with the normal functions of these tissues. As the TTR protein fibrils enlarge, more tissue damage occurs and the disease worsens, resulting in poor quality of life and eventually death. Worldwide, there are an estimated 300,000 - 500,000 patients with amyloid transthyretin cardiomyopathy (ATTR-CM)[1,2] and 10,000 - 40,000 patients with amyloid transthyretin polyneuropathy (ATTR-PN).[3]
AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com (https://www.astrazeneca.com/) and follow the Company on Twitter @AstraZeneca (https://twitter.com/AstraZeneca).
Contacts
For details on how to contact the Investor Relations Team, please click here (https://www.astrazeneca.com/investor-relations.html#Contacts). For Media contacts, click here (https://www.astrazeneca.com/media-centre/contacts.html).
References
1. Mohamed-Salem L, et al. Prevalence of wild type ATTR assessed as myocardial uptake in bone scan in the elderly population. Int J Cardiol. 2018 Nov 1;270:192-196. doi: 10.1016/j.ijcard.2018.06.006.
2. Cuscaden C, et al. Estimation of prevalence of transthyretin (ATTR) cardiac amyloidosis in an Australian subpopulation using bone scans with echocardiography and clinical correlation. J Nucl Cardiol. 2020 May 8. doi: 10.1007/s12350-020-02152-x.
3. González-Duarte A, et al. Impact of non-cardiac clinicopathologic characteristics on survival in transthyretin amyloid polyneuropathy. Neurol Ther. 2020;9(1):135-149. doi:10.1007/s40120-020-00183-7.