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ListaSmall Cap Stockholm
Abliva är ett läkemedelsbolag. Bolaget utvecklar läkemedel för behandling av primära mitokondriella sjukdomar. Dessa medfödda, sällsynta och ofta mycket svåra sjukdomar uppstår då cellens energiförsörjare, mitokondrierna, inte fungerar som de ska. Portföljen omfattar projekt i olika skeden och sträcker sig från tidig upptäcktsfas till klinisk fas. Bolaget gick tidigare under namnet NeuroVive Pharmaceutical.
2023-11-14 20:15:00

Abliva AB (‘Abliva’ or the ‘Company’) and US-based Owl Therapeutics today announced the signing of a licensing and collaboration agreement for Abliva’s NeuroSTAT® for the treatment of moderate to severe traumatic brain injury (TBI).

Under the agreement, Owl Therapeutics (San Antonio, Texas), a clinical-stage biopharmaceutical company focused on the development of diagnostic-powered therapeutics for traumatic brain injury (TBI) and brain health, will receive a global (excluding China and South Korea) license to develop, manufacture, and commercialize NeuroSTAT.

Under the terms of the agreement, Abliva is eligible to receive up to $43.65 million in milestones (excluding royalties), $1.15 million of which will be paid upon realization of specific clinical and regulatory milestones, with a further up to $42.5 million payable on achievement of commercial related milestones. In addition, Abliva is eligible for mid-single digit royalties (based on net sales) upon commercialization. Owl Therapeutics will be responsible for all costs associated with the development, manufacture, and commercialization of NeuroSTAT. Given the collaborative nature of the agreement, the Abliva team will remain involved in the program and will contribute to the operational and strategic elements of the program. Abliva will contribute by way of an agreed and time-limited commitment with respect to certain Abliva team members.

“NeuroSTAT has been an important asset at Abliva for many years, and we are delighted to have found the right partner to take this program through development and to patients throughout the world who suffer from TBI. We are pleased that this agreement ensures Abliva expertise will be available as Owl drives the program forward, as well as has the potential to provide significant economics to Abliva,” said Ellen Donnelly, CEO of Abliva.

"Abliva stands out as an exceptional partner for Owl Therapeutics, and we are excited to join forces in our collective commitment to advance NeuroSTAT," said William E. Haskins, Co-Founder and Chief Executive Officer of Gryphon Bio, which wholly owns Owl Therapeutics. "We are thrilled to focus our team's scientific, clinical, and business experience on this potentially game-changing treatment for military and civilian TBI patients."

TBI is a significant public health concern, affecting millions of individuals annually through accidents, falls, sports injuries and military combat. TBI occurs when a sudden external force or impact to the head disrupts normal brain function, leading to a wide range of cognitive, physical, and emotional symptoms. The far-reaching impact of TBI extends beyond the individual patient, exerting a substantial economic burden on healthcare systems and society. Additionally, the emotional and financial toll on affected individuals and their families underscores the pressing need for continued research and advancements in TBI prevention, diagnosis, and treatment. Efforts in this direction are crucial to not only improve patient outcomes but also alleviate the socioeconomic consequences of this complex and pervasive health issue.