The abstract reports updated immunological findings from the ongoing Phase 1 dose‑escalation study (NCT06205849). The study assesses mitazalimab when injected directly into the tumor at the time of surgical IRE in patients with locally advanced PDAC after standard-of-care chemotherapy.

The abstract highlights that all six patients with completed pre‑ and post‑treatment analyses demonstrated T‑cell reactivity to patient‑specific neoantigens. Overall, neoantigen reactivity increased significantly following treatment, indicating that mitazalimab + IRE results in an expansion of tumor specific T cells.

“Scientific interest in mitazalimab continues to grow, not least through the momentum we see in our investigator-initiated trials,” said Søren Bregenholt, CEO of Alligator Bioscience. “The data presented at AACR provide further evidence of the mechanistic potential of CD40 agonism to enhance antitumor immunity, even in difficult-to-treat cancers such as pancreatic cancer. We greatly value the engagement from leading academic centers who are exploring mitazalimab in innovative clinical settings, reflecting the continued confidence in its therapeutic promise.”

Abstract details
Title: Irreversible electroporation (IRE) with intratumoral CD40 antibody increases T cell reactivity to personalized neoantigens in locally advanced pancreatic cancer
Time: Monday, 20 April 2026, 09:00 am – 12:00 pm PDT
Session: PO.CTP01.01 – Phase I Clinical Trials in Progress, Section 51
Presenter: Dr. Rebekah R. White, UC San Diego School of Medicine, La Jolla, CA

The accepted abstract is available at aacr.org.