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Cantargia ASCO presentation highlights positive clinical data on nadunolimab counteracting neuropathy
Prenumeration
Beskrivning
| Land | Sverige |
|---|---|
| Lista | Small Cap Stockholm |
| Sektor | Hälsovård |
| Industri | Bioteknik |
Cantargia (Cantargia AB; Nasdaq Stockholm: CANTA) today gave a presentation at the ASCO conference showing clinical data on nadunolimab counteracting the serious problem of chemotherapy induced neuropathy, an additional positive finding beyond its promising antitumor effects. The data focus on 73 pancreatic cancer patients receiving nadunolimab and chemotherapy. A key finding is higher dose levels of nadunolimab correlated to lower incidence of neuropathy. This protective effect is further supported by strong preclinical findings on neuropathy induced by two different types of chemotherapy. The new results can be accessed at Cantargia’s webpage www.cantargia.com.
“The ASCO presentation, highlighting these unique new data on nadunolimab, is an important opportunity for Cantargia to meet with the key stake holders in oncology and take the next step in the development of nadunolimab,” said Göran Forsberg, CEO of Cantargia.
The key data were published in a press release May 23. Major findings are: The incidence of neuropathy was notably lower than expected from chemotherapy treatment in the 73 first line pancreatic cancer patients treated with nadunolimab and gemcitabine/nab-paclitaxel. Only one grade 3 event was observed and a statistically significant (p=0.042) relationship between dose level and any grade neuropathy was observed. At 1 mg/kg nadunolimab, 60% of patients had any grade neuropathy with a median time to onset of 112 days. At 2.5 mg/kg or higher, only 36% had any grade neuropathy and median time to onset was not reached. The efficacy also shows signals of activity with median survival of 13.2 months and iPFS of 7.2 months, both longer than expected from historical control data for the chemotherapy alone (1).
Studies in mouse models show that several aspects of chemotherapy induced neuropathy, such as sensitivity to mechanical pressure, temperature and decreased grip strength, all were prevented by concomitant treatment with the nadunolimab surrogate antibody. Combination studies were performed with either paclitaxel or vincristine and all results were statistically significant.
Neuropathy is a serious medical condition and a side effect of several classes of chemotherapies. The main symptoms are weakness, pain and numbness in hands and feet. Neuropathy often leads to discontinuation of therapy in patients despite effective antitumor activity. The mechanisms behind chemotherapy induced neuropathy relate to damaged nerve cells and neuroinflammation, where the IL-1 pathway has been indicated as a key driver.
The preclinical data were generated in collaboration with Hana Starobova and colleagues at University of Queensland, Australia. The results were presented by Prof. Eric van Cutsem, UZ Leuven Gashuisberg, Belgium at the ASCO Annual Meeting May 31st - June 4th, 2024, in Chicago, USA and the poster has been published on Cantargia’s website www.cantargia.com.
Reference
1) OS 8.5 mo, PFS 5.3 mo, (Von Hoff et al, N Engl J Med 2013); OS 9.2 mo, PFS 5.6 mo, (Wainberg et al, Lancet 2023)