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2025-11-19 07:00 Kvartalsrapport 2025-Q3
2025-08-21 07:00 Kvartalsrapport 2025-Q2
2025-05-16 - X-dag ordinarie utdelning CANTA 0.00 SEK
2025-05-15 - Årsstämma
2025-05-13 - Kvartalsrapport 2025-Q1
2025-02-21 - Bokslutskommuniké 2024
2024-12-02 - Extra Bolagsstämma 2025
2024-11-15 - Kvartalsrapport 2024-Q3
2024-08-28 - Kvartalsrapport 2024-Q2
2024-05-24 - X-dag ordinarie utdelning CANTA 0.00 SEK
2024-05-23 - Årsstämma
2024-05-21 - Kvartalsrapport 2024-Q1
2024-02-22 - Bokslutskommuniké 2023
2023-11-10 - Kvartalsrapport 2023-Q3
2023-08-22 - Kvartalsrapport 2023-Q2
2023-05-24 - X-dag ordinarie utdelning CANTA 0.00 SEK
2023-05-23 - Årsstämma
2023-05-23 - Kvartalsrapport 2023-Q1
2023-02-23 - Bokslutskommuniké 2022
2022-11-10 - Kvartalsrapport 2022-Q3
2022-08-30 - Kvartalsrapport 2022-Q2
2022-07-21 - Extra Bolagsstämma 2022
2022-05-24 - X-dag ordinarie utdelning CANTA 0.00 SEK
2022-05-23 - Årsstämma
2022-05-23 - Kvartalsrapport 2022-Q1
2022-02-24 - Bokslutskommuniké 2021
2021-11-11 - Kvartalsrapport 2021-Q3
2021-08-19 - Kvartalsrapport 2021-Q2
2021-05-27 - X-dag ordinarie utdelning CANTA 0.00 SEK
2021-05-26 - Årsstämma
2021-05-26 - Kvartalsrapport 2021-Q1
2021-02-25 - Bokslutskommuniké 2020
2020-11-12 - Kvartalsrapport 2020-Q3
2020-10-13 - Extra Bolagsstämma 2020
2020-08-20 - Kvartalsrapport 2020-Q2
2020-05-28 - X-dag ordinarie utdelning CANTA 0.00 SEK
2020-05-27 - Årsstämma
2020-05-27 - Kvartalsrapport 2020-Q1
2020-02-27 - Bokslutskommuniké 2019
2019-11-15 - Kvartalsrapport 2019-Q3
2019-08-22 - Kvartalsrapport 2019-Q2
2019-05-28 - X-dag ordinarie utdelning CANTA 0.00 SEK
2019-05-27 - Årsstämma
2019-05-27 - Kvartalsrapport 2019-Q1
2019-02-27 - Bokslutskommuniké 2018
2018-11-15 - Kvartalsrapport 2018-Q3
2018-08-21 - Kvartalsrapport 2018-Q2
2018-06-01 - X-dag ordinarie utdelning CANTA 0.00 SEK
2018-05-31 - Årsstämma
2018-05-15 - Kvartalsrapport 2018-Q1
2018-02-28 - Bokslutskommuniké 2017
2017-11-15 - Kvartalsrapport 2017-Q3
2017-08-23 - Kvartalsrapport 2017-Q2
2017-05-31 - X-dag ordinarie utdelning CANTA 0.00 SEK
2017-05-30 - Årsstämma
2017-05-15 - Kvartalsrapport 2017-Q1
2017-03-15 - Bokslutskommuniké 2016
2017-01-16 - Extra Bolagsstämma 2017
2016-11-21 - Kvartalsrapport 2016-Q3
2016-08-24 - Kvartalsrapport 2016-Q2
2016-05-25 - Årsstämma
2016-05-16 - Kvartalsrapport 2016-Q1
2016-03-02 - X-dag ordinarie utdelning CANTA 0.00 SEK
2016-03-01 - Bokslutskommuniké 2015
2015-11-17 - Kvartalsrapport 2015-Q3
2015-08-25 - Kvartalsrapport 2015-Q2
2015-05-19 - Kvartalsrapport 2015-Q1
2015-03-03 - Bokslutskommuniké 2014

Beskrivning

LandSverige
ListaSmall Cap Stockholm
SektorHälsovård
IndustriBioteknik
Cantargia är verksamt inom läkemedelsbranschen och fokuserar på utveckling av behandlingar för cancer och inflammatoriska sjukdomar. Bolaget forskar på nya terapier som kan förbättra patientresultat och livskvalitet. Verksamheten är global med en huvudsaklig närvaro i Europa och Nordamerika. Cantargia grundades 2009 och har sitt huvudkontor i Lund.
2025-05-19 07:30:00
  • IL1RAP expression positively correlates with inflammatory markers in human atherosclerotic plaques.
  • IL1RAP blocking antibodies inhibit endothelial activation and neutrophil adhesion induced by IL-1, IL-33 and IL-36.
  • IL1RAP targeted therapy offers a novel strategy to mitigate vascular inflammation.

Cantargia (Cantargia AB (publ); Nasdaq Stockholm: CANTA) today announced the publication of preclinical results from IL1RAP targeting antibodies in models of vascular inflammation. Cytokines dependent on IL1RAP strongly affect human endothelial cells to induce release of proinflammatory mediators, attract immune cells and increase vascular permeability. These changes can be potently blocked by antibodies targeting IL1RAP. Also, IL1RAP levels in human atherosclerotic lesions correlate with various inflammatory markers, indicating translational possibility into human cardiovascular diseases (CVDs). The results are published in the Journal of the American Heart Association (JAHA).

“IL1RAP and its ligands, IL-1, IL-33 and IL-36, are central for inflammation not only because of their effects on immune cells but also due to effects on other cells that respond to inflammation. The work now published show how IL1RAP-targeting antibodies can block inflammation by acting directly on endothelial cells and potentially reduce events important in several inflammatory diseases, including CVD” said David Liberg, CSO of Cantargia

Vascular inflammation is a central part of several inflammatory diseases, including atherosclerosis. The current findings revealed that IL1RAP targeting antibodies inhibit the IL-1β, IL-33 and IL-36γ induced release of inflammatory and chemotactic mediators and genes related to endothelial activation and adhesion. Concordantly, endothelial permeability and neutrophil adhesion were inhibited by antibodies blocking IL1RAP. Analysis of human atherosclerotic plaques showed a correlation between the levels of IL1RAP and several of the inflammatory markers reduced by IL1RAP blockade, including interleukin-6 and -8 (IL-6 and IL-8).

These data signify IL1RAP as a key regulator in vascular inflammation and in maintaining vascular integrity, which in turn implies targeting IL1RAP may have promising potential in several inflammatory diseases, including CVD.

“Inflammation is a central hallmark of atherosclerosis, and our research shows that targeting IL1RAP inhibits important inflammatory markers central in atherosclerosis. The established collaboration with Cantargia is very valuable both for us and for development of therapeutic options within CVDs” said Associate Professor Karin H Franzén, Örebro University

These data were generated in collaboration with Associate Professor Karin Franzén’s research group at Örebro University. The article, titled “IL1RAP expression in human atherosclerosis - a target of novel antibodies to reduce vascular inflammation and adhesion”, by Lindkvist et al., is available at Journal of the American Heart Associations website and at Cantargias website.