Lördag 21 December | 15:37:19 Europe / Stockholm

Prenumeration

Kalender

Tid*
2025-02-20 08:30 Bokslutskommuniké 2024
2024-11-13 - Kvartalsrapport 2024-Q3
2024-08-22 - Kvartalsrapport 2024-Q2
2024-05-10 - X-dag ordinarie utdelning GUARD 0.00 SEK
2024-05-08 - Årsstämma
2024-05-08 - Kvartalsrapport 2024-Q1
2024-02-21 - Bokslutskommuniké 2023
2023-12-15 - Split GUARD 50:1
2023-11-10 - Kvartalsrapport 2023-Q3
2023-08-24 - Kvartalsrapport 2023-Q2
2023-05-10 - X-dag ordinarie utdelning GUARD 0.00 SEK
2023-05-09 - Årsstämma
2023-05-09 - Kvartalsrapport 2023-Q1
2023-02-24 - Extra Bolagsstämma 2023
2023-02-22 - Bokslutskommuniké 2022
2022-12-13 - Extra Bolagsstämma 2022
2022-11-16 - Kvartalsrapport 2022-Q3
2022-08-23 - Kvartalsrapport 2022-Q2
2022-05-13 - X-dag ordinarie utdelning GUARD 0.00 SEK
2022-05-12 - Årsstämma
2022-05-12 - Kvartalsrapport 2022-Q1
2022-02-22 - Bokslutskommuniké 2021
2021-11-18 - Kvartalsrapport 2021-Q3
2021-11-08 - Extra Bolagsstämma 2021
2021-08-19 - Kvartalsrapport 2021-Q2
2021-05-14 - X-dag ordinarie utdelning GUARD 0.00 SEK
2021-05-12 - Årsstämma
2021-05-12 - Kvartalsrapport 2021-Q1
2021-02-24 - Bokslutskommuniké 2020
2020-11-18 - Kvartalsrapport 2020-Q3
2020-09-07 - Extra Bolagsstämma 2020
2020-08-20 - Kvartalsrapport 2020-Q2
2020-05-15 - X-dag ordinarie utdelning GUARD 0.00 SEK
2020-05-14 - Årsstämma
2020-05-14 - Kvartalsrapport 2020-Q1
2020-02-27 - Bokslutskommuniké 2019
2019-11-27 - Kvartalsrapport 2019-Q3
2019-10-23 - Extra Bolagsstämma 2019
2019-08-27 - Kvartalsrapport 2019-Q2
2019-05-31 - X-dag ordinarie utdelning GUARD 0.00 SEK
2019-05-29 - Årsstämma
2019-05-21 - Kvartalsrapport 2019-Q1
2019-03-20 - Bokslutskommuniké 2018
2019-01-24 - Extra Bolagsstämma 2018
2018-11-21 - Kvartalsrapport 2018-Q3
2018-08-22 - Kvartalsrapport 2018-Q2
2018-06-01 - X-dag ordinarie utdelning GUARD 0.00 SEK
2018-05-31 - Årsstämma
2018-05-23 - Kvartalsrapport 2018-Q1
2018-02-23 - Bokslutskommuniké 2017
2017-11-22 - Kvartalsrapport 2017-Q3
2017-08-25 - Kvartalsrapport 2017-Q2
2017-05-24 - Kvartalsrapport 2017-Q1
2017-05-19 - Split GUARD 20:1
2017-04-28 - X-dag ordinarie utdelning GUARD 0.00 SEK
2017-04-27 - Årsstämma
2017-03-14 - Extra Bolagsstämma 2017
2017-02-22 - Bokslutskommuniké 2016
2016-11-18 - Kvartalsrapport 2016-Q3
2016-08-19 - Kvartalsrapport 2016-Q2
2016-05-03 - Extra Bolagsstämma 2016
2016-04-28 - X-dag ordinarie utdelning GUARD 0.00 SEK
2016-04-27 - Årsstämma
2016-04-22 - Kvartalsrapport 2016-Q1
2016-02-19 - Bokslutskommuniké 2015
2015-11-02 - Extra Bolagsstämma 2015
2015-10-30 - Kvartalsrapport 2015-Q3
2015-08-20 - Kvartalsrapport 2015-Q2
2015-05-29 - Kvartalsrapport 2015-Q1
2015-05-18 - Årsstämma
2015-04-29 - X-dag ordinarie utdelning GUARD 0.00 SEK
2015-02-18 - Bokslutskommuniké 2014
2014-11-19 - Kvartalsrapport 2014-Q3
2014-10-13 - Extra Bolagsstämma 2014
2014-08-20 - Kvartalsrapport 2014-Q2
2014-04-14 - Kvartalsrapport 2014-Q1
2014-04-03 - Split GUARD 1:5
2014-03-26 - X-dag ordinarie utdelning GUARD 0.00 SEK
2014-03-25 - Årsstämma
2014-02-21 - Bokslutskommuniké 2013
2013-11-12 - Kvartalsrapport 2013-Q3
2013-08-15 - Kvartalsrapport 2013-Q2
2013-05-22 - Årsstämma
2013-05-15 - Kvartalsrapport 2013-Q1

Beskrivning

LandSverige
ListaFirst North Stockholm
SektorHälsovård
IndustriBioteknik
Guard Therapeutics bedriver utveckling av läkemedel inom området oxidativ stress. Bolaget fokuserar i första hand på forskning, utveckling och kommersialisering av läkemedel som avser att förhindra uppkomst och komplikationer av akuta njurskador. Läkemedlet har i prekliniska studier visat sig skydda exponerad vävnad och understödja regenerativa processer. Behandling av akuta njurskador i samband med hjärtkirurgi prioriteras i den kliniska utvecklingen.
2022-09-05 10:45:00

Guard Therapeutics today announces that the first patient has been dosed in a Phase 1b clinical trial of the investigational drug RMC-035 (ROSgard) in kidney transplantation. The company has thus achieved an important milestone by expanding the clinical development program to a second indication where RMC-035 has the potential to protect against acute kidney injuries. Full study results are expected to be available in the first half of 2023.

Guard Therapeutics' investigational drug RMC-035 has in preclinical studies demonstrated favorable treatment effects in several models of acute kidney injury, for example linked to oxygen deficiency (so-called ischemia-reperfusion injuries). The efficacy of RMC-035 is already being evaluated in a comprehensive global Phase 2 study (AKITA) to demonstrate its ability to prevent and treat acute kidney injury in patients undergoing open heart surgery.
 
The current Phase 1b study of RMC-035 is open-label, without control group, and will include 8–12 patients undergoing kidney transplantation at Karolinska University Hospital in Huddinge. Initially, eight patients will be enrolled in two sequential dose groups, after which an interim analysis of the pharmacokinetic properties of RMC-035 will be conducted. Based on the outcome of this analysis, a potential third dose group may be evaluated. The primary endpoint of the study includes key pharmacokinetic properties of RMC-035, and the results will inform on the design of a potential subsequent Phase 2 study aimed at improving renal function in kidney transplant recipients.
 
"The Phase 1b study marks the start of an expansion of the clinical development program for RMC-035 to another area with a high need for novel and improved therapies. Based on the mechanism of action of our investigational drug, we see significant opportunities to counteract specific kidney injuries that occur in relation to kidney transplantation and that often leads to both short-term and long-term medical complications in patients, even after successful transplantation", says Guard Therapeutics CEO, Tobias Agervald.