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LandDanmark
ListaMid Cap Copenhagen
SektorHälsovård
IndustriMedicinteknik
Gubra är ett läkemedelsbolag. Bolagets verksamhet är fokuserad på de tidiga stadierna av läkemedelsutveckling. De driver huvudsakligen forskning och utveckling inom området för metabola och fibrotiska sjukdomar.. Bolagets produktportfölj innefattar ett flertal varumärken och läkemedel, och verksamheten bedrivs på global nivå, med störst närvaro inom Nordamerika och Norden. Huvudkontoret ligger i Hørsholm, Danmark.
2023-06-09 07:30:00

Gubra today announces updates to its R&D pipeline of internal and partnered projects. Most notably is the addition of a new CNS (orexin) peptide drug discovery project, now ready for partnering. The aim of the project is to develop an efficacious and safe peptide-based treatment for narcolepsy type 1.

Henrik Blou, CEO at Gubra, is satisfied with the latest pipeline developments:
 
“We are pleased to add this new CNS indication to our portfolio of drug discovery projects. The exciting results suggest that we can use streaMLine to develop blood-brain-barrier penetrating peptides which has tremendous potential in multiple CNS-related disorders.”
 
Gubra has developed a broad series of orexin peptides with very promising effects in animal models of narcolepsy which spurred the decision to advance the project into their R&D pipeline. The orexin peptide drug discovery project, that gains access to brain orexin receptors after a subcutaneous injection, has grown out of Gubra’s own streaMLine platform for rapid peptide drug discovery.
 
Orexin is a hormone that helps regulate sleep-wake cycles. Certain sleeping disorders, such as narcolepsy type 1 (narcolepsy with cataplexy), are debilitating diseases with severe consequences for the quality of life of patients and their relatives. They are believed to be caused by the loss of a group of neurons deep in the brain producing orexin peptides. Narcolepsy type 1 is a rare chronic neurological disorder with a prevalence of 25-50 per 100,000.