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Beskrivning
Land | Sverige |
---|---|
Lista | First North Stockholm |
Sektor | Hälsovård |
Industri | Bioteknik |
Nanexa AB announces that initial observations in the phase I study show that the 30 mg dose of NEX-22, a depot formulation of liraglutide, has been well tolerated by patients with type 2 diabetes who have not previously received GLP-1 treatment.
A disadvantage of liraglutide given as daily injections is a high incidence of early gastrointestinal side effects such as nausea and diarrhea, and requires a cautious dose escalation to an effective daily dose (1.2 mg). After an injection of NEX-22 with 30 mg liraglutide released over a month, no nausea, vomiting or diarrhea was observed in the three patients dosed.
Two patients experienced decreased appetite, one of them in combination with heartburn. All observations were mild and transient and are also commonly seen with GLP-1 treatment. Observations at the injection site also show that the 30 mg dose has been well tolerated, with only limited skin reactions of minor and transient nature.
"These are very positive results!" says David Westberg, CEO of Nanexa. " The fact that NEX-22 can be administered at a dose of 30 mg liraglutide without causing nausea, vomiting, and diarrhea, which are all common gastrointestinal side effects associated with GLP-1s, shows great potential benefits. We look forward to further presenting all the results from the study."
The follow-up of patients continues to monitor the concentration of liraglutide in the blood just over a month, along with evaluation of safety and tolerability.
For additional information, please contact:
David Westberg – CEO, Nanexa AB (publ)
Phone: +46 70 942 83 03
Email: david.westberg@nanexa.se
www.nanexa.com
The company’s Certified Adviser is Carnegie Investment Bank AB (publ).
About Nanexa AB (publ)
Nanexa is a pharmaceutical company developing injectable drug products based on the proprietary and innovative drug delivery system PharmaShell® – the high drug load delivery system enabling the next generation long-acting injectables through atomic layer precision. Nanexa develops its own products and also has collaboration agreements with several pharma companies, among others Novo Nordisk and AstraZeneca.
Nanexa’s share is listed on Nasdaq First North Growth Market in Stockholm (NANEXA).