08:58:24 Europe / Stockholm

Kurs & Likviditet

Kursutveckling och likviditet under dagen för detta pressmeddelande

Prenumeration

Kalender

2024-11-28 Kvartalsrapport 2024-Q3
2024-08-29 Kvartalsrapport 2024-Q2
2024-05-29 Kvartalsrapport 2024-Q1
2024-05-27 X-dag ordinarie utdelning SANION 0.00 SEK
2024-05-25 Årsstämma 2024
2024-02-29 Bokslutskommuniké 2023
2024-01-16 Extra Bolagsstämma 2024
2023-11-30 Kvartalsrapport 2023-Q3
2023-08-31 Kvartalsrapport 2023-Q2
2023-05-25 Årsstämma 2023
2023-05-25 Kvartalsrapport 2023-Q1
2023-05-24 X-dag ordinarie utdelning SANION 0.00 SEK
2023-02-23 Bokslutskommuniké 2022
2022-11-17 Kvartalsrapport 2022-Q3
2022-08-25 Kvartalsrapport 2022-Q2
2022-08-18 Extra Bolagsstämma 2022
2022-05-27 X-dag ordinarie utdelning SANION 0.00 SEK
2022-05-25 Årsstämma 2022
2022-05-25 Kvartalsrapport 2022-Q1
2022-02-24 Bokslutskommuniké 2021
2021-11-18 Kvartalsrapport 2021-Q3
2021-09-16 Extra Bolagsstämma 2021
2021-08-26 Kvartalsrapport 2021-Q2
2021-05-27 X-dag ordinarie utdelning SANION 0.00 SEK
2021-05-26 Kvartalsrapport 2021-Q1
2021-05-26 Årsstämma 2021
2021-03-17 Bokslutskommuniké 2020
2020-11-30 Kvartalsrapport 2020-Q3
2020-10-23 Extra Bolagsstämma 2020
2020-08-27 Kvartalsrapport 2020-Q2
2020-05-28 X-dag ordinarie utdelning SANION 0.00 SEK
2020-05-06 Kvartalsrapport 2020-Q1
2020-05-06 Årsstämma 2020
2020-02-07 Extra Bolagsstämma 2019
2020-02-07 Bokslutskommuniké 2019
2019-11-13 Kvartalsrapport 2019-Q3
2019-08-21 Kvartalsrapport 2019-Q2
2019-05-31 X-dag ordinarie utdelning SANION 0.00 SEK
2019-05-29 Kvartalsrapport 2019-Q1
2019-05-29 Årsstämma 2019
2019-02-21 Bokslutskommuniké 2018
2018-11-14 Kvartalsrapport 2018-Q3
2018-08-22 Kvartalsrapport 2018-Q2
2018-05-25 X-dag ordinarie utdelning SANION 0.00 SEK
2018-05-24 Kvartalsrapport 2018-Q1
2018-05-24 Årsstämma 2018
2018-02-21 Bokslutskommuniké 2017
2018-01-19 Extra Bolagsstämma 2018
2017-11-15 Kvartalsrapport 2017-Q3
2017-08-23 Kvartalsrapport 2017-Q2
2017-05-24 X-dag ordinarie utdelning SANION 0.00 SEK
2017-05-23 Årsstämma 2017
2017-05-11 Kvartalsrapport 2017-Q1
2017-02-21 Bokslutskommuniké 2016
2016-10-13 Extra Bolagsstämma 2016
2016-05-11 X-dag ordinarie utdelning SANION 0.00 SEK
2016-05-10 Årsstämma 2016
2016-05-10 Kvartalsrapport 2016-Q1
2016-02-19 Bokslutskommuniké 2015
2015-11-20 Kvartalsrapport 2015-Q3
2015-09-04 Extra Bolagsstämma 2015
2015-08-31 Kvartalsrapport 2015-Q2
2015-05-21 X-dag ordinarie utdelning SANION 0.00 SEK
2015-05-20 Kvartalsrapport 2015-Q1
2015-05-20 Årsstämma 2015
2015-02-20 Bokslutskommuniké 2014
2014-11-21 Kvartalsrapport 2014-Q3
2014-08-22 Kvartalsrapport 2014-Q2

Beskrivning

LandDanmark
ListaSmall Cap Stockholm
SektorHälsovård
IndustriBioteknik
Saniona är verksamt inom bioteknik. Idag bedrivs forskning och utveckling av läkemedel för behandling av nervsjukdomar samt övriga autoimmuna sjukdomar. Läkemedelsportföljen är bred och innefattar läkemedel som för närvarande befinner sig i olika kliniska faser. En del av arbetet utförs även i samarbete med andra aktörer inom läkemedelsbranschen. Saniona har huvudkontor i Glostrup.
2023-11-21 08:00:00

Saniona (OMX: SANION), a clinical stage biopharmaceutical company, today announced that it has initiated the candidate selection phase with a proprietary subtype selective frontrunner molecule from the Kv7 lead optimization program for epilepsy. The compound has a unique selectivity profile and represents a potential new generation of effective and well tolerated epilepsy medicines.

“It is very satisfying that after only one year in lead optimization, we can initiate the final testing with the aim of selecting a candidate for preclinical development. The Kv7 channel field is one of the most promising target areas for the treatment of epilepsy, and we are experiencing great commercial interest in our program", says Thomas Feldthus, CEO of Saniona.

“Our Kv7 compound has a truly new and innovative mode-of-actions and selectivity profile, and the rapid identification of the compound was only possible due to our very robust research platform, IonBaseTM, characterized by fast turn-around chemistry, biological testing, database integration and IP-protection. I am convinced that our innovative Kv7 compound profile represents a new generation of effective and well tolerated epilepsy medicines with potential for use in other brain disorders including depression and bipolar disorder,” said Palle Christophersen, EVP Research.

Epilepsy, a brain disorder characterized by recurrent seizures, affects millions of people worldwide. There is considerable unmet need since about 30 percent of the patients are unresponsive to current medicines.

Kv7 channels mediate potassium ion transport across the cell membrane of neurons, which decreases the likelihood of generating uncontrolled nerve impulses. Activators of Kv7 channels are therefore very effective in dampening overactive neurons and thus prevent the generation of epileptic seizures. Mutations in Kv7 channels containing the Kv7.2 and Kv7.3 subunits are the second most common cause of inherited severe childhood epilepsies, which demonstrate their importance in controlling nerve cell activity.

The non-selective Kv7 activator retigabine has provided both clinical and commercial proof-of-concept for treatment of patients with resistant focal onset seizures. Retigabine has also shown anti-epileptic effect and developmental improvement in smaller investigator-driven studies with children with loss-of-function mutations in Kv7.2. However, retigabine has been withdrawn from the market due to compound specific and non-target related side-effects.

The Kv7 channel family comprise five subtypes, of which channels consisting of Kv7.2 and Kv7.3 subunits are selectively expressed in the brain. The Saniona program focuses on development of subtype selective Kv7.2/Kv7.3 activators, thus avoiding retigabine´s troublesome side effects on the CNS and urinary system, which caused a high drop-out rate in the clinical studies and eventually resulted in quite low adherence to the drug despite good efficacy.