The aim of the project is to develop novel microcystin-based payloads for antibody-drug conjugates (ADCs), with the potential to significantly improve cancer therapy. Simris Biologics is specifically focused on creating ADCs with substantially enhanced efficacy and minimal or no side effects for improved safety in ADC treatments. Our unique mechanism of action of microcystins—derived from cyanobacteria—offers a promising alternative to conventional cytotoxic agents currently used in Oncology therapies.

Dr. Alexis Roberts-McIntosh, CEO of Simris Group, stated: “A key feature of this project is the targeted molecular modification of microcystins using Simris’ patented methods. These allow for precise optimization, selective conjugation to antibodies, and fluorescent labeling. This enables not only improved efficacy and tolerability through targeted release of cancer-specific microcystins in tumor tissue, but also visualization and tracking of the therapy within the body—marking a significant advancement in personalized medicine.“

The optimized and labeled microcystin payloads will be evaluated in ADC format through preclinical in vitro and in vivo testing and subsequently licensed to the pharmaceutical industry.

Simris Biologics thanks all project participants and the project sponsor for their trust and support. With KlicMic, another important step is being taken towards the development of low-side-effect, targeted cancer therapy.

Simris Biologics’s expertise and world leading cyanobacterial toxin library will enable it to play a crucial role in the timely development of the next generation of ADCs that should significantly improve the treatment outcomes of cancer patients globally. Simris Biologics intends to achieve this goal through collaboration with a broad range of strategic partners.

Supported by:
Federal Ministry for Economic Affairs and Energy
ZIM Zentrales Innovationsprogramm Mittelstand
on basis of a decision by the German Bundestag