Targinta presents positive preclinical data on the antibody-drug conjugate TARG9
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Beskrivning
| Land | Sverige |
|---|---|
| Lista | First North Stockholm |
| Sektor | Hälsovård |
| Industri | Medicinteknik |
The oncology company Targinta, a wholly owned subsidiary of Xintela AB (publ), presents new preclinical data on the antibody-drug conjugate TARG9 at the 2nd Integrin-Targeted Drug Development Summit, Boston, on September 1, 2022 at 11 a.m. local time (17:00 CEST).
Targinta develops first-in-class tumor-targeting antibodies and antibody-drug conjugates (ADCs) against the unique and patent protected target integrin α10β1. This cell adhesion receptor is highly expressed in some aggressive cancers such as glioblastoma but not at all in most normal tissues, making it an attractive target for ADCs.
TARG9 is a new generation ADC armed with a very potent cytotoxin. The concept builds on the fact that the tumor-targeting antibody delivers the cytotoxin very selectively to cancer cells, killing these but saving normal cells. The new data presented at the 2nd Integrin-Targeted Drug Development Summit in Boston includes the demonstration of strong and specific binding of TARG9 to integrin α10β1. Further, TARG9 was found to internalize at a high rate and to induce cell death of integrin α10β1-expressing glioblastoma cells, even at low picomolar concentrations. And importantly, a single dose of TARG9 effectively inhibited tumor growth for more than 2 months in a preclinical glioblastoma model.
“The observed effects on tumor growth are truly impressive and gives strong support for the continued development of TARG9", says Per Norlén, CEO of Targinta.
For further information please contact:
Per Norlén, CEO Targinta AB
Email: per.norlen@targinta.se
Phone: +46 46 275 65 00
About Targinta
Targinta is a preclinical stage oncology biotech company, developing first-in-class tumor-targeting antibodies and antibody-drug conjugates (ADCs) for aggressive cancers based on the in-house discovery of the novel patent-protected cancer target integrin α10β1. The pipeline includes TARG10, a function-blocking intergrin α10-antibody that is being developed to prevent metastasis, and TARG9, an intergrin α10-ADC that is armed with a powerful toxin that selectively kills tumor cells. Targinta is a wholly owned subsidiary of Xintela AB (publ) and is headquartered in Lund, Sweden. For more information, please visit www.targinta.se.
About Xintela
Xintela develops medical products in stem cell therapy and targeted cancer therapy based on the Company's cell surface marker integrin α10β1 which is found on mesenchymal stem cells and on certain aggressive cancer cells. The stem cell marker is used to select and quality-assure the patent-protected stem cell product XSTEM®, which is in clinical development for treatment of knee osteoarthritis and difficult-to-heal leg ulcers. The company produces XSTEM for the clinical studies in its GMP-approved manufacturing facility. In cancer therapy, which is run by the wholly owned subsidiary Targinta AB, therapeutic antibodies, targeting integrin α10β1 (First-in-Class) are being developed for the treatment of triple-negative breast cancer and the brain tumor glioblastoma. Xintela conducts its business at Medicon Village in Lund, Sweden, and is listed on Nasdaq First North Growth Market Stockholm since 22 March 2016. Xintela's Certified Adviser at Nasdaq First North Growth Market is Erik Penser Bank AB, +46 8-463 80 00, certifiedadviser@penser.se.