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Arctic Bioscience announces that new research on herring roe oil (HRO) and phospholipid esters from herring roe (PEHeRo) has been accepted for publication in the Journal of Lipid Research, an internationally recognized scientific journal in the field of lipid biology.
The study shows that HRO and its phospholipids (PEHeRo) activates the body's own inflammation-resolving mechanisms by increasing the production of specialized pro-resolving mediators (SPMs) in human immune cells and in a skin cell model relevant for psoriasis. SPMs are naturally occurring molecules derived from omega-3 fatty acids that help the body calm and resolve inflammation.
"We are very pleased to see these results published in a high-quality, peer-reviewed journal. This reinforces the strong scientific foundation built by our team. The findings further strengthen our understanding of how our investigational medicine HRO350 may help the body regulate inflammation, which is directly relevant for diseases like psoriasis," says CEO Christer L. Valderhaug.
The study demonstrates that treatment with herring roe phospholipids leads to a clear increase in several lipid mediator families, including mediators known to support resolution of inflammation and tissue repair. The results were consistent across both immune cells and skin cells involved in psoriatic disease processes.
"This research provides important insight into how HRO350 may work at a cellular level in psoriasis and generally in immune-mediated diseases. We are especially encouraged by the consistent activation of inflammation-resolving pathways. This supports the scientific foundation of our clinical development program," says Medical Director Runhild Gammelsæter.
HRO350 is currently in development as a potential new oral treatment option for mild-to-moderate psoriasis, a large patient population in need of therapies with favourable safety and tolerability profiles.
"Our R&D team has devoted a lot of time and resources to this project, and it is exciting to see the extracts we produce show targeted biological effects in state-of-the-art laboratory models," says CTO Daniele Mancinelli.
The research was carried out in collaboration with William Harvey Research Institute (UK), Nofima (Norway), and Møreforsking (Norway), and was partly supported by a grant from the Norwegian Research Council (project no. 327953).
Reference:
Ringheim-Bakka TA, Saliani A, Østbye TKK, Mildenberger J, Dooley M, Busygina M, Pedersen ME, Solberg NT, Dalli J, Gammelsæter R. Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture as model of psoriasis. Journal of Lipid Research (2026).