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2024-02-08 Bokslutskommuniké 2023
2023-11-09 Kvartalsrapport 2023-Q3
2023-08-10 Halvårsutdelning AZN 9.64
2023-07-28 Kvartalsrapport 2023-Q2
2023-04-27 Årsstämma 2023
2023-04-27 Kvartalsrapport 2023-Q1
2023-02-23 Halvårsutdelning AZN 20.69
2023-02-09 Bokslutskommuniké 2022
2022-11-10 Kvartalsrapport 2022-Q3
2022-08-11 Halvårsutdelning AZN 9.49
2022-07-29 Kvartalsrapport 2022-Q2
2022-04-29 Årsstämma 2022
2022-04-29 Kvartalsrapport 2022-Q1
2022-02-24 Halvårsutdelning AZN 18
2022-02-10 Bokslutskommuniké 2021
2021-11-12 Kvartalsrapport 2021-Q3
2021-08-12 Halvårsutdelning AZN 7.72
2021-07-29 Kvartalsrapport 2021-Q2
2021-05-11 Årsstämma 2021
2021-04-30 Kvartalsrapport 2021-Q1
2021-02-25 Halvårsutdelning AZN 15.76
2021-02-11 Bokslutskommuniké 2020
2020-11-05 Kvartalsrapport 2020-Q3
2020-08-13 Halvårsutdelning AZN 7.87
2020-07-30 Kvartalsrapport 2020-Q2
2020-04-29 Årsstämma 2020
2020-04-29 Kvartalsrapport 2020-Q1
2020-02-27 Halvårsutdelning AZN 18.32
2020-02-14 Bokslutskommuniké 2019
2019-10-24 Kvartalsrapport 2019-Q3
2019-08-08 Halvårsutdelning AZN 8.49
2019-07-25 Kvartalsrapport 2019-Q2
2019-04-26 Kvartalsrapport 2019-Q1
2019-04-26 Årsstämma 2019
2019-02-28 Halvårsutdelning AZN 17.46
2019-02-14 Bokslutskommuniké 2018
2018-11-08 Kvartalsrapport 2018-Q3
2018-08-09 Halvårsutdelning AZN 7.92
2018-07-26 Kvartalsrapport 2018-Q2
2018-05-18 Kvartalsrapport 2018-Q1
2018-05-18 Årsstämma 2018
2018-02-15 Halvårsutdelning AZN 14.97
2018-02-02 Bokslutskommuniké 2017
2017-11-09 Kvartalsrapport 2017-Q3
2017-08-10 Halvårsutdelning AZN 7.4
2017-07-27 Kvartalsrapport 2017-Q2
2017-04-27 Kvartalsrapport 2017-Q1
2017-04-27 Årsstämma 2017
2017-02-16 Halvårsutdelning AZN 16.57
2017-02-02 Bokslutskommuniké 2016
2016-11-10 Kvartalsrapport 2016-Q3
2016-08-11 Halvårsutdelning AZN 7.81
2016-07-28 Kvartalsrapport 2016-Q2
2016-04-29 Kvartalsrapport 2016-Q1
2016-04-29 Årsstämma 2016
2016-02-18 Halvårsutdelning AZN 16.26
2016-02-04 Bokslutskommuniké 2015
2015-11-05 Kvartalsrapport 2015-Q3
2015-08-13 Halvårsutdelning AZN 7.71
2015-07-30 Kvartalsrapport 2015-Q2
2015-04-24 Kvartalsrapport 2015-Q1
2015-04-24 Årsstämma 2015
2015-02-19 Halvårsutdelning AZN 15.62
2015-02-05 Bokslutskommuniké 2014
2014-11-06 Kvartalsrapport 2014-Q3
2014-08-13 Halvårsutdelning AZN 6.2
2014-07-31 Kvartalsrapport 2014-Q2
2014-04-24 Årsstämma 2014
2014-04-24 Kvartalsrapport 2014-Q1
2014-02-19 Halvårsutdelning AZN 12.41
2014-02-06 Bokslutskommuniké 2013
2013-10-31 Kvartalsrapport 2013-Q3
2013-08-14 Halvårsutdelning AZN 5.92
2013-08-01 Kvartalsrapport 2013-Q2
2013-08-01 Analytiker möte 2013
2013-04-25 Kvartalsrapport 2013-Q1
2013-04-25 Årsstämma 2013
2013-02-13 Halvårsutdelning AZN 12.08
2013-01-31 Bokslutskommuniké 2012
2012-10-25 Kvartalsrapport 2012-Q3
2012-10-25 Analytiker möte 2012
2012-08-08 Halvårsutdelning AZN 6.26
2012-07-26 Kvartalsrapport 2012-Q2
2012-04-26 Kvartalsrapport 2012-Q1
2012-04-26 Årsstämma 2012
2012-02-15 Halvårsutdelning AZN 13.21
2012-02-02 Bokslutskommuniké 2011
2011-10-27 Kvartalsrapport 2011-Q3
2011-08-03 Halvårsutdelning AZN 5.33
2011-07-28 Kvartalsrapport 2011-Q2
2011-04-28 Årsstämma 2011
2011-04-28 Kvartalsrapport 2011-Q1
2011-02-02 Halvårsutdelning AZN 11.99
2011-01-27 Bokslutskommuniké 2010
2010-10-28 Kvartalsrapport 2010-Q3
2010-08-04 Halvårsutdelning AZN 5.12
2010-07-29 Kvartalsrapport 2010-Q2
2010-04-29 Kvartalsrapport 2010-Q1
2010-02-03 Halvårsutdelning AZN 12.43
2010-01-28 Bokslutskommuniké 2009
2009-10-29 Kvartalsrapport 2009-Q3
2009-08-05 Halvårsutdelning AZN 4.41
2009-07-30 Kvartalsrapport 2009-Q2
2009-04-30 Kvartalsrapport 2009-Q1
2009-04-30 Årsstämma 1
2009-02-04 Halvårsutdelning AZN 12.02
2008-08-06 Halvårsutdelning AZN 3.34
2008-02-06 Halvårsutdelning AZN 8.61
2007-08-08 Halvårsutdelning AZN 3.49
2007-02-07 Halvårsutdelning AZN 8.6
2006-08-09 Halvårsutdelning AZN 3.6
2006-02-08 Halvårsutdelning AZN 7.02
2005-08-10 Halvårsutdelning AZN 2.99
2005-02-09 Halvårsutdelning AZN 4.497
2004-08-11 Halvårsutdelning AZN 2.2
2004-02-18 Halvårsutdelning AZN 3.91
2003-08-20 Halvårsutdelning AZN 2.07
2003-02-19 Halvårsutdelning AZN 3.99
2002-08-21 Halvårsutdelning AZN 2.21
2002-02-20 Halvårsutdelning AZN 5.01
2001-08-22 Halvårsutdelning AZN 2.44
2001-02-21 Halvårsutdelning AZN 4.49
2000-09-04 Halvårsutdelning AZN 2.1
2000-03-08 Halvårsutdelning AZN 4.01
1999-09-06 Halvårsutdelning AZN 1.89
1999-04-01 Split AZN 1:0.5045
1997-05-26 Split AZN 1:2
1993-06-14 Split AZN 1:5
1987-06-04 Split AZN 1:2


ListaLarge Cap Stockholm
IndustriLäkemedel & Handel
AstraZeneca är ett globalt läkemedelsbolag med fokus på forskning, utveckling och marknadsföring av receptbelagda läkemedel, primärt för behandling av sjukdomar inom terapiområdena som berör andningsvägar, hjärta/kärl/metabolism och cancer. Utöver huvudverksamheten är bolaget även aktiva inom autoimmunitet, neurovetenskap och infektion. AstraZeneca är verksamma inom samtliga globala regioner och har sitt huvudkontor i Cambridge, Storbritannien.
2023-08-16 16:02:43

FLAURA2 data reinforce Tagrisso as backbone therapy for EGFR-mutated advanced lung cancer in combination with chemotherapy; granted Breakthrough Therapy Designation in the US. Further results for Enhertu, Imfinzi and datopotamab deruxtecan showcase strength of diverse ADC and IO portfolios to address unmet needs.

AstraZeneca advances its robust lung cancer portfolio and pipeline at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer (WCLC), 9 to 12 September 2023.

More than 40 abstracts will feature eight approved and potential new medicines from AstraZeneca, including nine oral presentations and a late-breaking plenary Presidential Symposium presentation of results from the FLAURA2 Phase III trial (https://www.astrazeneca.com/media-centre/press-releases/2023/tagrisso-plus-chemo-improved-pfs-in-lung-cancer.html) of Tagrisso (osimertinib) in combination with chemotherapy for patients with locally advanced or metastatic epidermal growth factor receptor-mutated (EGFRm) lung cancer.

Dave Fredrickson, Executive Vice President, Oncology Business Unit, AstraZeneca, said: "Our data at WCLC support our ambition to have the right AstraZeneca medicine for more than half of all patients treated for lung cancer by 2030, and underscore the need to increase screening and early diagnosis to improve patient outcomes. The strong results from FLAURA2 will further establish Tagrisso as the backbone therapy in EGFR-mutated non-small cell lung cancer, and the recent Breakthrough Therapy Designation in the US is a significant validation of the potential we see for this regimen."

Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: "Following last year's accelerated approval of Enhertu as the first HER2-directed therapy for patients with previously treated HER2-mutant metastatic lung cancer, new data at WCLC will reinforce its potential benefit to patients in need of targeted options. In addition, data for datopotamab deruxtecan will further support the potential to combine this agent with immune checkpoint inhibitors and the continued investigation of these combinations in first-line settings."

Improving outcomes across early- and late-stage EGFRm lung cancer
A late-breaking plenary Presidential Symposium presentation will showcase progression-free survival (PFS) data from the FLAURA2 Phase III trial evaluating Tagrisso in combination with chemotherapy for patients with locally advanced (Stage IIIB-IIIC) or metastatic (Stage IV) EGFRm non-small cell lung cancer (NSCLC). In May, high-level results showed the Tagrisso combination demonstrated a statistically significant and clinically meaningful improvement in PFS compared to standard-of-care Tagrisso monotherapy. In August, Tagrisso plus chemotherapy was granted Breakthrough Therapy Designation in the US for advanced EGFRm NSCLC.

An oral presentation of results from a Phase IIIb trial will show the potential of Orpathys (savolitinib) as a 1st-line treatment for advanced or metastatic NSCLC harbouring MET exon 14 mutations. Orpathys is approved for this indication in China.

In addition, an e-poster on a computational pathology analysis of MET expression in patients treated with a combination of Orpathys and Tagrisso in the SAVANNAH Phase II trial will showcase the Company's progress in developing transformational technology solutions to identify patients who are most likely to respond to treatment. Encouraging efficacy for the combination has been previously reported in the same study in patients with high levels of MET overexpression and/or amplification whose disease progressed on treatment with Tagrisso.

Realising the potential of antibody drug conjugates (ADCs) in advanced lung cancer
A late-breaking oral presentation of first results from the TROPION-Lung04 Phase Ib trial will highlight the safety and efficacy of datopotamab deruxtecan (Dato-DXd) plus Imfinzi (durvalumab) with and without carboplatin in patients with previously treated or untreated, advanced or metastatic NSCLC without actionable genomic alterations. There are currently no TROP2-directed ADCs approved for the treatment of patients with lung cancer.

A mini-oral presentation of primary results from the DESTINY-Lung02 Phase II trial will share the first overall survival and PFS data for Enhertu (trastuzumab deruxtecan) in patients with previously treated HER2-mutant metastatic NSCLC. Enhertu is approved for this indication in a number of countries, including in the US, where it was granted accelerated approval based on interim results (https://www.astrazeneca.com/media-centre/press-releases/2022/enhertu-continues-to-demonstrate-clinically-meaningful-tumour-response-in-patients-with-her2-mutant-metastatic-non-small-cell-lung-cancer.html) from the trial.

Two posters will feature AZD9592, an EGFR/cMET bispecific ADC designed to deliver targeted chemotherapy to cancer cells expressing both EGFR and cMET with a topoisomerase inhibitor 1 warhead using the Company's proprietary linker technology. A trial-in-progress poster will describe the EGRET Phase I trial, a first-in-human study evaluating AZD9592 in patients with advanced solid tumours including in combination with Tagrisso in metastatic EGFRm NSCLC. In addition, a poster on translational results for AZD9592 suggests it may provide clinical benefit in areas of unmet need, including in patients with NSCLC previously treated with chemotherapy or targeted agents. This is the Company's first bispecific ADC to enter the clinic.

Reinforcing Imfinzi benefits alone and in novel combinations across lung cancer settings
Two late-breaking oral presentations will share new data from the AEGEAN Phase III trial of Imfinzi in combination with neoadjuvant chemotherapy before surgery and as adjuvant monotherapy after surgery in patients with resectable NSCLC, including key surgical outcomes and exploratory analyses of clinical outcomes in a subset of patients with EGFRm disease. Previously presented (https://www.astrazeneca.com/media-centre/press-releases/2023/imfinzi-based-treatment-before-and-after-surgery-reduced-the-risk-of-disease-recurrence-progression-events-or-death-in-resectable-non-small-cell-lung-cancer.html) primary results from AEGEAN demonstrated statistically significant and clinically meaningful improvement in event-free survival and pathologic complete response with this Imfinzi-based regimen versus neoadjuvant chemotherapy alone followed by surgery.

Another oral presentation of data from a planned subset analysis of the PACIFIC-R observational study of Imfinzi in a real-world population of patients with EGFRm disease will explore the long-term clinical outcomes of Imfinzi in patients with unresectable, Stage III NSCLC.

Data will also be shared from new exploratory subgroup analyses of the POSEIDON Phase III trial describing patients deriving long-term benefit from the combination of Imfinzi, Imjudo (tremelimumab) and chemotherapy in the metastatic NSCLC setting.

Advancing our commitment to increase lung cancer screening and early diagnosis
An oral presentation will describe a framework to support government implementation of high-quality and impactful lung cancer screening programmes. Screening is essential to early detection and reducing lung cancer mortality. Published in March 2023 (https://www.healthpolicypartnership.com/lung-cancer-policy-network-launches-framework-to-support-implementation-of-lung-cancer-screening/#:~:text=The%20Network%2C%20for%20which%20The%20Health%20Policy%20Partnership,readiness%20to%20implement%20a%20lung%20cancer%20screening%20programme.), the framework was developed by the Lung Cancer Policy Network, an initiative of the Lung Ambition Alliance (https://www.lungambitionalliance.com/our-alliance.html) aimed at elevating lung cancer as a policy priority worldwide. AstraZeneca is a founding member of the Lung Ambition Alliance, a global coalition working to accelerate innovation and deliver meaningful improvements for people with lung cancer, including and beyond treatment.

Collaboration in the scientific community is critical to improving outcomes for patients. AstraZeneca is collaborating with Daiichi Sankyo Company Limited to develop and commercialise Enhertu and datopotamab deruxtecan, and with HUTCHMED to develop and commercialise Orpathys.

Key AstraZeneca presentations during WCLC 2023

Lead Author Abstract Title Presentation details (SGT)
drivers and
Janne, PA Osimertinib Abstract #PL03.13
With/Without Plenary Session 3: Presidential Symposium
Platinum-Based 11 September 2023 9:40 AM
Chemotherapy as
Treatment in
Patients with
EGFRm Advanced
Lu, S A Phase 3b Study Abstract #OA21.03
of 1L Savolitinib Oral Session MET Matters in NSCLC12
in Patients with September 2023 2:32 PM
Locally Advanced
or Metastatic
NSCLC Harboring
MET Exon 14
Soo, R TARGET: A Phase Abstract #P1.25-09
II Study of 5 Poster Session Early-Stage Non-small Cell
-year Adjuvant Lung Cancer
Osimertinib in 10 September 2023 5:30 PM
Resected EGFR
-mutated Stage II
Tan, DSW OSTARA: A Phase Abstract #P2.09-17
II Study of First Poster Session Metastatic Non-small Cell
-line Osimertinib Lung Cancer - Targeted Therapy
Combined with 11 September 2023 6:00 PM
Amivantamab in
EGFRm Advanced
Non-Small Cell
Lung Cancer
Christ, S Computational Abstract #EP06.05-09
Pathology-Based E-Poster Session Pathology and Biomarkers
Assessment of On-Demand
Expression for
Patient Selection
in the Treatment
of MET
Antibody drug
Papadopoulos, Datopotamab Abstract #OA05.06
KP Deruxtecan (Dato Oral Session Antibody Drug Conjugates: The
-DXd) + Next Tsunami
Durvalumab ± 10 September 2023 3:32 PM
Carboplatin in
Initial Results
from Phase 1b
Janne, P Trastuzumab Abstract #MA13.10
Deruxtecan in Mini Oral Session Targeted Therapy: EGFR and
Patients with Her2
HER2-Mutant 11 September 2023 4:25 PM
Metastatic Non
-Small Cell Lung
Cancer: Primary
Results of
McGrath, L In Vivo Efficacy Abstract #P1.12-04
of AZD9592, an Poster Session Tumour Biology -
EGFR-cMET Translational Biology
Bispecific ADC, 10 September 2023 5:30 PM
in a Broad Panel
of NSCLC Patient
Xenograft Models
Aggarwal, C AVANZAR: Phase Abstract #P2.04-02
III Study of Poster Session Metastatic Non-small Cell
Datopotamab Lung Cancer - Cytotoxic Therapy
Deruxtecan (Dato 11 September 2023 6:00 PM
-DXd) +
Durvalumab +
Carboplatin as 1L
Treatment of
Aggarwal, C EGRET: First-in Abstract #P2.04-03
-human Study of Poster Session Metastatic Non-small Cell
the Novel Lung Cancer - Cytotoxic Therapy
Antibody-drug 11 September 2023 6:00 PM
Conjugate AZD9592
± Anti-cancer
Agents in
Advanced Solid
Zhou, C TROPION-Lung08: Abstract #P2.08-01
Datopotamab Poster Session Metastatic Non-small Cell
deruxtecan plus Lung Cancer - Immunotherapy
pembrolizumab in 11 September 2023 6:00 PM
c non-small cell
lung cancer
Mitsudomi, T Surgical outcomes Abstract #OA12.05
with neoadjuvant Oral Session Pushing the Boundaries:
durvalumab + Adjuvant and Neoadjuvant Approaches in Early
chemotherapy Stage Non-small Cell Lung Cancer
followed by 11 September 2023 12:22 PM
durvalumab in
resectable NSCLC
He, J Neoadjuvant Abstract #OA12.06
Durvalumab + Oral Session Pushing the Boundaries:
Chemotherapy Adjuvant and Neoadjuvant Approaches in Early
Followed by Stage Non-small Cell Lung Cancer
Adjuvant 11 September 2023 12:32 PM
Durvalumab in
Resectable EGFR
-mutated NSCLC
Peters, S Real-World Abstract #OA17.03
Outcomes with Oral Session Next Steps in Locally Advanced
Durvalumab After NSCLC: Optimizing Techniques & Choosing
Chemoradiotherapy Populations That Benefit
in Unresectable 11 September 2023 3:47 PM
-Mutated NSCLC
Cho, BC Durvalumab ± Abstract #P2.06-05
Tremelimumab + Poster Session Metastatic Non-small Cell
Chemotherapy in Lung Cancer - Immunotherapy
1L Metastatic 11 September 2023 6:00 PM
of patients with
PFS ≥12 months in
lung cancer
Lam, SC Taking A Health Abstract #OA16.03
Systems Approach Oral Session Expanding the Scope of Lung
to Low-Dose CT Cancer Screening Initiatives Worldwide
Lung Cancer 11 September 2023 3:47 PM
Screening: A
Bespoke Framework
to Support


AstraZeneca in oncology
AstraZeneca is leading a revolution in oncology with the ambition to provide cures for cancer in every form, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients.

The Company's focus is on some of the most challenging cancers. It is through persistent innovation that AstraZeneca has built one of the most diverse portfolios and pipelines in the industry, with the potential to catalyse changes in the practice of medicine and transform the patient experience.

AstraZeneca has the vision to redefine cancer care and, one day, eliminate cancer as a cause of death.

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com (http://www.astrazeneca.com/) and follow the Company on social media @AstraZeneca (https://www.linkedin.com/company/astrazeneca/mycompany/verification/).

For details on how to contact the Investor Relations Team, please click here (https://www.astrazeneca.com/investor-relations.html#Contacts). For media contacts, click here (https://www.astrazeneca.com/media-centre/contacts.html).