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Kurs & Likviditet
Beskrivning
| Land | Sverige |
|---|---|
| Lista | Nordic SME Sweden |
| Sektor | Hälsovård |
| Industri | Läkemedel & Handel |
The detection of proteins and peptides is necessary in many clinical diagnostics applications and has been of high importance during the pandemic. Detection using antibodies is well established due to their high specificities and selectivity. However, they have limited chemical- and physical stabilities concerning shelf lives and transport. This paper describes the development of synthetic antibodies with high stability, and the comparable specificity and selectivity for commercially available antibodies.
The team of Prof. Nicholls at the Linnaeus University describes how they have developed polymer nanoparticles against Oxytocin. They characterized the nanoparticles with light scattering, scanning- and transmission electron microscopy, and X-ray photoelectron spectroscopy. To determine the specificity and selectivity, they used Attana's Quartz Crystal Microbalance (QCM) technology, the Attana Cell™ 200 instrument and displayed an affinity of 0.3nM which could be compared to commercial polyclonal antibodies displaying an affinity of 0.02-0.2nM.
The work was partly financed by The Swedish Knowledge Foundation (Grant Nos: 20190114, 20170059)
Read the full publication here: https://www.mdpi.com/1422-0067/23/5/2534