The published article in Nature Communications is a peer-reviewed scientific documentation of the excellent COVID-19 immunization demonstration, with very high level of SARS-CoV-2 virus neutralization shown in a mice model, that was announced in June 2020.

The article is titled "Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity". Nature Communications is an online journal with papers that are citable via a digital object identifier (DOI) number. The DOI for this paper is 10.1038/s41467-020-20251-8. The paper will be available online at http://www.nature.com/ncomms.

CEO Bent Frandsen comments:          
"This peer-reviewed publication in Nature Communications adds further credibility to the robustness of the excellent COVID-19 immunization data of the ABNCoV2 vaccine that was announced in June 2020. The generation of such strong data for a novel vaccine concept, while working under severe time constraints, would not have been possible without the outstanding team effort of the PREVENT-nCoV consortium. For ExpreS[2]ion, it is also great to have our unique ExpreS[2] protein production system cited in yet another Nature publication. Furthermore, it is also very encouraging that our joint venture partner AdaptVac's unique cVLP system has been able to achieve such a high level of well-documented preclinical efficacy".

About the cVLP COVID-19 vaccine product

ExpreS[2]ion and its joint venture partner AdaptVac are engaged in the development of a unique capsid virus-like particle (VLP) COVID-19 vaccine, partly sponsored through a Horizon 2020 EU grant award (https://news.cision.com/expres2ion-biotechnologies/r/expres2ion-announces-eu-grant-award-for-the-covid-19-vaccine-development-programme,c3054055) to the PREVENT-nCoV consortium to rapidly advance the vaccine candidate against COVID-19 into the clinic. This vaccine technology has the potential to mimic a virus to the body's immune system, giving the optimal stimulus to generate a fast, long-lasting immune response that offers a highly-efficacious protection. Importantly, the production of the vaccine technology can be readily scaled to commercial quantities and ExpreS[2]ion and AdaptVac are working with AGC Biologics for the manufacture and scale-up of the vaccine (https://news.cision.com/expres2ion-biotechnologies/r/expres2ion-announces-selection-of-agc-biologics-as-manufacturing-partner-for-the-covid-19-vaccine-an,c3094798). Bavarian Nordic has licensed the commercialization rights (https://news.cision.com/expres2ion-biotechnologies/r/expres2ion-s-joint-venture-adaptvac-signs-final-license-agreement-with-bavarian-nordic-on-covid-19-v,c3157573) to the cVLP COVID-19 vaccine and variants hereof.

About the PREVENT-nCoV consortium

The consortium is funded by an EU Horizon 2020 grant to develop a COVID-19 vaccine. Further the vaccine development at University of Copenhagen is supported by the Carlsberg Foundation, the research councils and Gudbjørg og Ejnar Honorés Fond. The consortium members are world-leading experts in their respective fields, covering all relevant areas of viral research and vaccine development required for rapid clinical development of a COVID-19 vaccine. This includes pre-clinical and clinically validated experience from working with similar Coronaviruses such as MERS and SARS, ExpreS[2]ion's Drosophila S2 insect cell expression system, and AdaptVac's capsid virus-like particle (cVLP) technology. In addition to ExpreS[2]ion (http://www.expres2ionbio.com) and AdaptVac (http://www.AdaptVac.com), the consortium members are Leiden University Medical Center (LUMC (http://www.lumc.nl/)), Institute for Tropical Medicine (ITM (http://www.medizin.uni-tuebingen.de/en-de/das-klinikum/einrichtungen/kliniken/medizinische-klinik/tropenmedizin)) at University of Tübingen, The Department of Immunology and Microbiology (ISIM (https://isim.ku.dk/)) at University of Copenhagen, and the Laboratory of Virology at Wageningen University (https://www.wur.nl/).

About AdaptVac

AdaptVac (http://www.AdaptVac.com.) is a joint venture between ExpreS[2]ion Biotechnologies and NextGen Vaccines, owned by the inventors of the novel proprietary and ground-breaking capsid virus-like particle (cVLP) platform technology spun out from the University of Copenhagen. AdaptVac aims to accelerate the development of highly efficient therapeutic and prophylactic vaccines within high value segments of oncology, infectious diseases and immunological disorders. Granting of the core patent in the U.S. has expanded AdaptVac's patent protection to include the full pipeline of vaccines and immunotherapies in development.

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