Treating GBM and TNBC is notoriously difficult. Traditional chemotherapy struggles with issues such as poor drug solubility, toxicity, and, in the case of brain tumors, the blood-brain barrier - a natural defense that blocks many drugs from reaching the tumor.

To tackle these challenges, the research team tested two innovative drug delivery systems:

• Polymeric micelles made from two commercially available systems
• Dendritic nanogels (DNGs) based on Polymer Factory's proprietary bis-MPA dendritic nanotechnology

These nanocarriers were designed to encapsulate and transport common chemotherapy agents like docetaxel, carboplatin, and doxorubicin, increasing their stability and effectiveness. The results were encouraging:
- DNGs were especially effective at delivering water-soluble drugs, offering high loading capacity.
- Micelles improved solubility and uptake of water-insoluble drugs like docetaxel.
- Both systems showed strong tumor penetration and significantly reduced cancer cell growth in
laboratory tests.

"This study represents a meaningful step forward in precision oncology," said Mats Wallnér, CEO of Polymer Factory. "By improving how cancer drugs are delivered, we can potentially make treatments both safer and more effective for patients with hard-to-treat tumors."
The findings not only offer hope for future cancer therapies but also highlight the potential of polymer-based nanotechnology in personalized medicine.