Oslo, Norway 26 February 2025 - Circio Holding ASA (OSE: CRNA), a biotechnology
company developing powerful circular RNA technology for next generation nucleic
acid medicine, today announces that CEO Dr. Erik Digman Wiklund and CSO Dr.
Victor Levitsky have been invited to present the circVec platform and benefits
of circular RNA at two upcoming biopharma industry conferences in Basel,
Switzerland, and Stockholm, Sweden.

The presentations will detail the advantages and potential of circular RNA to
improve on current mRNA-based technology for a range of therapeutic
applications. Circio's latest circVec 3.0 generation demonstrates significantly
increased and prolonged protein expression, with up to 75 times half-life
extension for circRNA compared to conventional linear mRNA in mouse models.

RNA Leaders Europe Congress (https://informaconnect.com/rna-leaders
-europe/agenda/2/)
Title: Deploying circular RNA expression to boost gene therapy - AAV and beyond
Time & place: 5 March 2025, 11:05 CET, Basel, Switzerland
Presenter: Dr. Erik Digman Wiklund, CEO

Biologics World Nordics 2025 (https://www.imapac.com/events/biologics-world
-nordics-2025)
Title: CircVec - A Novel Payload Expression Platform Based on Circular RNA
Biogenesis: Features and Opportunities
Time & place: 5 March 2025, 11:35 CET, Stockholm, Sweden
Presenter: Dr. Victor Levitsky, CSO

These invitations to present at important RNA industry conferences highlight
CircioŽs position as a leader in circRNA placed along other pioneering RNA
companies such as Alnylam, CureVac and Sail Biomedicines. It follows the recent
invitation by Nature Review Genetics to author a comprehensive review article on
the therapeutic potential of synthetic circular RNA and vector-based circular
RNA expression.

The presentations will be made available on CircioŽs webpage on the respective
dates.

For further information, please contact:
Erik Digman Wiklund, CEO
Phone: +47 413 33 536
Email: erik.wiklund@circio.com

Neil Hunter - Hunter PR
Phone:+44 7821 255568 (http://tel:+447821255568)
Email: neiljameshunter@gmail.com

About Circio

Building next generation RNA technology for nucleic acid medicine

Circio Holding ASA is a biotechnology company developing powerful circular RNA
vector expression technology for next generation nucleic acid medicine.

Circio has established a unique circular RNA (circRNA) vector expression
platform for novel DNA, RNA and viral therapeutics. The proprietary circVec
technology is based on a modular genetic cassette design for efficient
biogenesis of multifunctional circRNA inside cells, which can be deployed in
multiple therapeutic settings, including genetic medicine, cell therapy and
chronic disease. The circVec platform has demonstrated up to 15-fold enhanced
and more significantly more durable protein expression vs. classic mRNA vector
systems and has the potential to become a new gold-standard platform technology
for nucleic acid and viral therapeutics in the future. The circRNA R&D
activities are being conducted by the wholly owned subsidiary Circio AB based at
the Karolinska Institute in Stockholm, Sweden.

In addition, Circio is developing a pan-RAS cancer vaccine, TG01, targeting KRAS
driver mutations. TG01 is currently being tested in two clinical trials: RAS
-mutated pancreatic and lung cancer in the USA and multiple myeloma in Norway.
These studies are being run through academic and industry collaborative
networks, supported by prestigious research grants from Innovation Norway and
the Norwegian Research Council, creating read-outs and future optionality for
the program at low cost to Circio.