· Circio joins Georgetown University-sponsored phase 2 clinical trial to test
TG01 mutant RAS cancer vaccine in combination with daratumumab from Janssen and
nivolumab from BMS
  · The innovative combination will be tested in immunotherapy-resistant
pancreatic and lung cancer and led by world-renowned immunotherapy expert Prof.
Samir N. Khleif
  · The trial has been given approval to proceed by the US Food and Drug
Administration (FDA), and will start enrolling patients by the end of 2023

Oslo, Norway, 16 November 2023 - Circio Holding ASA (OSE: CRNA), a biotechnology
company developing novel circular RNA and immunotherapy medicines, today
announces that it has entered into a collaboration with Georgetown University as
part of a collaborative research support agreement with Janssen Scientific
Affairs, LLC (Janssen) and a drug supply agreement with Bristol Myers Squibb
(BMS) to test its drug candidate TG01 in combination with daratumumab (anti
-CD38) and nivolumab (anti-PD1) in patients with RAS-mutated pancreatic cancer
and patients with non-small cell lung cancer (NSCLC).

Mutations in the RAS-family of genes are a major cause of cancer and found in
over 90% of pancreatic and 30% of NSCLC cancer patients. RAS-mutated cancers
typically have poor prognosis, and few targeted treatment options exist. The
only approved RAS-targeting pharmaceuticals are small molecule inhibitors of the
specific G12C KRAS mutation, which covers around 40% of RAS-mutated lung
cancers, and the medical need for novel treatment alternatives for mutant RAS
cancer remains high. Furthermore, anti-PD1 resistance is emerging as a major
problem in immunotherapy, and more than 80% of patients with advanced tumors
still do not respond to such treatment.

To further study this unmet medical need, Georgetown University is pursuing a
phase 2 study to test the combination of daratumumab provided by Janssen,
nivolumab provided by BMS, and TG01 provided by Circio in immunotherapy-naïve
pancreatic cancer and in anti-PD1 resistant NSCLC. The scientific hypothesis
behind the study is based on ground-breaking research led and published by Prof.
Samir Khleif and colleagues, demonstrating that elimination of dysfunctional CD8
T-cells by anti-CD38, followed by priming of new effector T-cells by a cancer
vaccine, reinstated and strengthened efficacy of PD1 checkpoint blockade in pre
-clinical models.

Prof. Samir Khleif, Georgetown University, said: "Resistance to checkpoint
blockade remains one of the most challenging problems in treating cancer
patients and represents a significant unmet medical need. We are very pleased to
have established this collaboration to test a novel immunotherapy combination
regimen with the intention of overcoming immunotherapy resistance. The
combination of anti-CD38, anti-PD1 and a cancer vaccine has demonstrated highly
potent in preclinical in vivo models, and we are eager to evaluate how these
findings will translate in the clinic."

The trial will be led by Georgetown University in Washington D.C, USA. The
triple therapy combination will be tested in 54 patients in total, 27
immunotherapy-naïve KRAS-mutated patients with pancreatic cancer and 27 KRAS
-mutated patients with NSCLC who have progressed on prior anti-PD1 therapy.

Dr. Erik Digman Wiklund, Chief Executive Officer of Circio Holding ASA, added:
"We continue to see increasing interest in our mutant KRAS program, and the
Georgetown phase 2 study will be the third investigator-sponsored clinical trial
with the enhanced TG01 vaccine. This will be the first time TG01 is tested in
lung and non-resectable pancreatic cancer, potentially opening up new
indications for future development. Collaborations such as this is at the core
of the TG01 development strategy, and shows that we are continuing to execute on
our strategy of advancing our KRAS program through external development in
multiple settings and geographies."

Circio has been awarded two prestigious research grants from Innovation Norway
(IN) and the Norwegian Research Council (NRC) to advance the TG program in
several clinical studies. This phase 2 trial at Georgetown will be the first
study where TG01 is combined with anti-CD38 and anti-PD1, and the first time the
vaccine is tested in NSCLC. Circio will be responsible for TG01 drug supply and
scientific support towards specific KRAS-related immunological assays, supported
through the IN and NRC research grants. Janssen will contribute with funding for
the study and daratumumab supply, and BMS will provide supply of nivolumab. The
study protocol has been approved by the US FDA, and it is anticipated that the
first patient will be enrolled at Georgetown before the end of 2023.

For further information, please contact:
Erik Digman Wiklund, CEO
Phone: +47 413 33 536
Email: erik.wiklund@circio.com (erik.wiklund@targovax.com)

Renate Birkeli, Investor Relations
Phone: +47 922 61 624
Email: renate.birkeli@circio.com (renate.birkeli@targovax.com)

About Circio

Building next generation RNA therapeutics

Circio Holding ASA is a biotechnology company developing novel circular RNA and
immunotherapy medicines.

Circio has established a unique circular RNA (circRNA) platform to develop novel
circRNA medicines for rare disease, vaccines, and cancer. The proprietary
circVec technology is based on a modular genetic cassette design for efficient
biogenesis of multifunctional circRNA from DNA and viral vectors, which can be
deployed for many purposes. The circVec platform has demonstrated enhanced and
more durable protein expression than classic mRNA vector systems, and has the
potential to become the new gold-standard for DNA and virus-based therapeutics
in the future. The circRNA R&D activities are being conducted by the wholly
owned subsidiary Circio AB based at the Karolinska Institute in Stockholm,
Sweden.

In addition, Circio is developing a cancer vaccine, TG01, targeting KRAS driver
mutations. TG01 is currently being tested in two clinical trials in RAS-mutated
pancreatic cancer and multiple myeloma in the USA and Norway. These studies are
being run through academic collaborative networks, supported by prestigious
research grants from Innovation Norway and the Norwegian Research Council,
creating read-outs and future optionality for the program at low cost to Circio.