Fredag 14 Mars | 20:19:53 Europe / Stockholm

Kalender

Est. tid*
2025-11-05 07:30 Kvartalsrapport 2025-Q3
2025-08-06 07:30 Kvartalsrapport 2025-Q2
2025-05-07 07:30 Kvartalsrapport 2025-Q1
2025-03-28 N/A X-dag halvårsutdelning NOVO B 7.9
2025-03-27 N/A Årsstämma
2025-02-05 - Bokslutskommuniké 2024
2024-11-06 - Kvartalsrapport 2024-Q3
2024-08-15 - X-dag halvårsutdelning NOVO B 3.5
2024-08-07 - Kvartalsrapport 2024-Q2
2024-05-02 - Kvartalsrapport 2024-Q1
2024-03-22 - X-dag halvårsutdelning NOVO B 6.4
2024-03-21 - Årsstämma
2024-01-31 - Bokslutskommuniké 2023
2023-11-02 - Kvartalsrapport 2023-Q3
2023-09-13 - Split NOVO B 1:2
2023-08-18 - X-dag halvårsutdelning NOVO B 6
2023-08-10 - Kvartalsrapport 2023-Q2
2023-05-04 - Kvartalsrapport 2023-Q1
2023-03-24 - X-dag halvårsutdelning NOVO B 8.15
2023-03-23 - Årsstämma
2023-02-01 - Bokslutskommuniké 2022
2022-11-02 - Kvartalsrapport 2022-Q3
2022-08-12 - X-dag halvårsutdelning NOVO B 4.25
2022-08-04 - Kvartalsrapport 2022-Q2
2022-05-04 - Kvartalsrapport 2022-Q1
2022-03-25 - X-dag halvårsutdelning NOVO B 6.9
2022-03-24 - Årsstämma
2022-02-02 - Bokslutskommuniké 2021
2021-11-03 - Kvartalsrapport 2021-Q3
2021-08-16 - X-dag halvårsutdelning NOVO B 3.5
2021-08-05 - Kvartalsrapport 2021-Q2
2021-05-05 - Kvartalsrapport 2021-Q1
2021-03-26 - X-dag halvårsutdelning NOVO B 5.85
2021-03-25 - Årsstämma
2021-02-03 - Bokslutskommuniké 2020
2020-10-30 - Kvartalsrapport 2020-Q3
2020-08-14 - X-dag halvårsutdelning NOVO B 3.25
2020-08-06 - Kvartalsrapport 2020-Q2
2020-05-06 - Kvartalsrapport 2020-Q1
2020-03-27 - X-dag halvårsutdelning NOVO B 5.35
2020-03-26 - Årsstämma
2020-02-05 - Bokslutskommuniké 2019
2019-11-01 - Kvartalsrapport 2019-Q3
2019-08-21 - Kvartalsrapport 2019-Q2
2019-08-16 - X-dag halvårsutdelning NOVO B 3
2019-05-03 - Kvartalsrapport 2019-Q1
2019-03-22 - X-dag halvårsutdelning NOVO B 5.15
2019-03-21 - Årsstämma
2019-02-01 - Bokslutskommuniké 2018
2018-08-18 - X-dag halvårsutdelning NOVO B 3
2018-08-17 - X-dag halvårsutdelning NOVO B 3
2018-08-08 - Kvartalsrapport 2018-Q2
2018-05-02 - Kvartalsrapport 2018-Q1
2018-03-23 - X-dag halvårsutdelning NOVO B 4.85
2018-03-22 - Årsstämma
2018-02-01 - Bokslutskommuniké 2017
2017-11-01 - Kvartalsrapport 2017-Q3
2017-08-18 - X-dag halvårsutdelning NOVO B 3
2017-08-09 - Kvartalsrapport 2017-Q2
2017-05-03 - Kvartalsrapport 2017-Q1
2017-03-24 - X-dag ordinarie utdelning NOVO B 4.60 DKK
2017-03-23 - Årsstämma
2017-02-02 - Bokslutskommuniké 2016
2016-10-28 - Kvartalsrapport 2016-Q3
2016-08-12 - X-dag halvårsutdelning NOVO B 3
2016-08-05 - Kvartalsrapport 2016-Q2
2016-04-29 - Kvartalsrapport 2016-Q1
2016-03-21 - X-dag halvårsutdelning NOVO B 6.4
2016-03-18 - Årsstämma
2016-02-03 - Bokslutskommuniké 2015
2015-10-29 - Kvartalsrapport 2015-Q3
2015-08-06 - Kvartalsrapport 2015-Q2
2015-04-30 - Kvartalsrapport 2015-Q1
2015-03-20 - X-dag ordinarie utdelning NOVO B 5.00 DKK
2015-03-19 - Årsstämma
2015-01-30 - Bokslutskommuniké 2014
2014-10-30 - Kvartalsrapport 2014-Q3
2014-08-07 - Kvartalsrapport 2014-Q2
2014-05-01 - Kvartalsrapport 2014-Q1
2014-03-21 - X-dag ordinarie utdelning NOVO B 4.50 DKK
2014-03-20 - Årsstämma
2014-02-03 - Bokslutskommuniké 2013
2014-01-02 - Split NOVO B 1:5
2013-10-31 - Kvartalsrapport 2013-Q3
2013-08-08 - Kvartalsrapport 2013-Q2
2013-05-01 - Kvartalsrapport 2013-Q1
2013-03-21 - X-dag ordinarie utdelning NOVO B 18.00 DKK
2013-03-20 - Årsstämma
2013-02-04 - Bokslutskommuniké 2012
2012-10-31 - Kvartalsrapport 2012-Q3
2012-08-09 - Kvartalsrapport 2012-Q2
2012-04-27 - Kvartalsrapport 2012-Q1
2012-03-22 - X-dag ordinarie utdelning NOVO B 14.00 DKK
2012-03-21 - Årsstämma
2012-02-02 - Bokslutskommuniké 2011
2011-10-27 - Kvartalsrapport 2011-Q3
2011-08-04 - Kvartalsrapport 2011-Q2
2011-04-28 - Kvartalsrapport 2011-Q1
2011-03-24 - X-dag ordinarie utdelning NOVO B 10.00 DKK
2011-03-23 - Årsstämma
2011-02-02 - Bokslutskommuniké 2010
2010-03-25 - X-dag ordinarie utdelning NOVO B 7.50 DKK
2007-12-03 - Split NOVO B 1:2
2001-04-04 - Split NOVO B 1:5
1997-01-02 - Split NOVO B 1:2

Beskrivning

LandDanmark
ListaLarge Cap Copenhagen
SektorHälsovård
IndustriLäkemedel & Handel
Novo Nordisk är en producent av insulin för diabetesbehandling. Utöver specialistkompetensen inom diabetes producerar bolaget läkemedel för hormonbehandling samt produkter för hemofili och blödningsrubbningar. Produkterna återfinns på en global marknad och säljs under separata varumärken. Bolaget grundades ursprungligen under 1923 och har sitt huvudkontor i Bagsværd, Danmark.
2025-03-10 11:24:12

Bagsværd, Denmark, 10 March 2025 – Today, Novo Nordisk announced headline results from REDEFINE 2, a phase 3 trial in the global REDEFINE programme. REDEFINE 2 is a 68-week efficacy and safety trial investigating once-weekly subcutaneous CagriSema (a fixed dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg) compared to placebo. The trial included 1,206 randomised people with obesity or overweight and type 2 diabetes and a mean baseline body weight of 102 kg.

The trial achieved its primary endpoint by demonstrating a statistically significant and superior weight loss at week 68 with CagriSema versus placebo.

The REDEFINE 2 trial was based on a flexible protocol, allowing patients to modify their dosing throughout the trial. After 68 weeks, 61.9% of patients treated with CagriSema were on the highest dose.

When evaluating the effects of treatment, if all people adhered to treatment1, people treated with CagriSema achieved a superior weight loss of 15.7% after 68 weeks compared to 3.1% with placebo. Weight loss of 5% or more after 68 weeks was a co-primary endpoint and was achieved by 89.7% of patients on CagriSema, compared to 30.3% by placebo.

When applying the treatment policy estimand2, people treated with CagriSema achieved a superior weight loss of 13.7% compared to 3.4% with placebo.

In the trial, CagriSema appeared to have a safe and well-tolerated profile. The most common adverse events with CagriSema were gastrointestinal, and the vast majority were mild to moderate and diminished over time, consistent with the GLP-1 receptor agonist class.

“The REDEFINE 2 results confirmed the superior efficacy of CagriSema in people with overweight or obesity and type 2 diabetes”, said Martin Holst Lange, executive vice president for Development at Novo Nordisk. “We look forward to bringing this second pivotal trial to regulatory authorities with the aim of making this next-generation therapy available to the millions of patients in need.”

Novo Nordisk expects to file for the first regulatory approval of CagriSema in the first quarter of 2026. The detailed results from REDEFINE 1 and REDEFINE 2 will be presented at a scientific conference in 2025.

About CagriSema
Once-weekly subcutaneous CagriSema is being investigated by Novo Nordisk as a treatment for adults with overweight or obesity (REDEFINE programme) and as a treatment for adults with type 2 diabetes (REIMAGINE programme). CagriSema is a fixed-dose combination of a long-acting amylin analogue, cagrilintide 2.4 mg and semaglutide 2.4 mg. The two molecules induce weight loss by reducing hunger, increasing feelings of fullness and thereby helping people eat less and reduce their calorie intake.
        
About the REDEFINE clinical trial programme
REDEFINE is a phase 3 clinical development programme with once-weekly subcutaneous CagriSema in obesity. The global clinical trial programme consists of two pivotal phase 3 trials, which have enrolled approximately 4,600 adults with overweight or obesity. The phase 3 trial programme includes:

REDEFINE 1 – a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema, cagrilintide 2.4 mg and semaglutide 2.4 mg versus placebo in 3,417 adults with obesity or overweight with one or more comorbidities and without type 2 diabetes.

REDEFINE 2 – a 68-week efficacy and safety phase 3 trial of once-weekly CagriSema versus placebo in 1,200 adults with type 2 diabetes and either obesity or overweight.

REDEFINE 3 – an event-driven cardiovascular outcomes phase 3 trial of once-weekly CagriSema versus placebo in 7,000 adults with established cardiovascular disease with or without type 2 diabetes.

REDEFINE 4 – an 84-week efficacy and safety phase 3 trial of once-weekly CagriSema versus once-weekly tirzepatide 15 mg in 800 adults with obesity.

About Novo Nordisk
Novo Nordisk is a leading global healthcare company founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 76,300 people in 80 countries and markets its products in around 170 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com, Facebook, Instagram, X, LinkedIn and YouTube.  

Contacts for further information

Media: 
Ambre James-Brown
+45 3079 9289
ambre@novonordisk.com

Liz Skrbkova (US)
+1 609 917 0632
lzsk@novonordisk.com

Investors: 
Jacob Martin Wiborg Rode 
+45 3075 5956 
jrde@novonordisk.com 

 
Sina Meyer  
+45 3079 6656 
azey@novonordisk.com 

Ida Schaap Melvold
 +45 3077 5649
idmg@novonordisk.com
Max Ung 
+45 3077 6414  
mxun@novonordisk.com  

 
Frederik Taylor Pitter  
+1 609 613 0568 
fptr@novonordisk.com 

 
 

Company announcement No 11 / 2025



1 Based on the trial product estimand according to the trial protocol, regardless of dose strength
2 Based on the treatment policy estimand: treatment effect regardless of treatment adherence