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2024-11-06 - Kvartalsrapport 2024-Q3
2024-08-15 - X-dag halvårsutdelning NOVO B 3.5
2024-08-07 - Kvartalsrapport 2024-Q2
2024-05-02 - Kvartalsrapport 2024-Q1
2024-03-22 - X-dag halvårsutdelning NOVO B 6.4
2024-03-21 - Årsstämma
2024-01-31 - Bokslutskommuniké 2023
2023-11-02 - Kvartalsrapport 2023-Q3
2023-09-13 - Split NOVO B 1:2
2023-08-18 - X-dag halvårsutdelning NOVO B 6
2023-08-10 - Kvartalsrapport 2023-Q2
2023-05-04 - Kvartalsrapport 2023-Q1
2023-03-24 - X-dag halvårsutdelning NOVO B 8.15
2023-03-23 - Årsstämma
2023-02-01 - Bokslutskommuniké 2022
2022-11-02 - Kvartalsrapport 2022-Q3
2022-08-12 - X-dag halvårsutdelning NOVO B 4.25
2022-08-04 - Kvartalsrapport 2022-Q2
2022-05-04 - Kvartalsrapport 2022-Q1
2022-03-25 - X-dag halvårsutdelning NOVO B 6.9
2022-03-24 - Årsstämma
2022-02-02 - Bokslutskommuniké 2021
2021-11-03 - Kvartalsrapport 2021-Q3
2021-08-16 - X-dag halvårsutdelning NOVO B 3.5
2021-08-05 - Kvartalsrapport 2021-Q2
2021-05-05 - Kvartalsrapport 2021-Q1
2021-03-26 - X-dag halvårsutdelning NOVO B 5.85
2021-03-25 - Årsstämma
2021-02-03 - Bokslutskommuniké 2020
2020-10-30 - Kvartalsrapport 2020-Q3
2020-08-14 - X-dag halvårsutdelning NOVO B 3.25
2020-08-06 - Kvartalsrapport 2020-Q2
2020-05-06 - Kvartalsrapport 2020-Q1
2020-03-27 - X-dag halvårsutdelning NOVO B 5.35
2020-03-26 - Årsstämma
2020-02-05 - Bokslutskommuniké 2019
2019-11-01 - Kvartalsrapport 2019-Q3
2019-08-21 - Kvartalsrapport 2019-Q2
2019-08-16 - X-dag halvårsutdelning NOVO B 3
2019-05-03 - Kvartalsrapport 2019-Q1
2019-03-22 - X-dag halvårsutdelning NOVO B 5.15
2019-03-21 - Årsstämma
2019-02-01 - Bokslutskommuniké 2018
2018-08-18 - X-dag halvårsutdelning NOVO B 3
2018-08-08 - Kvartalsrapport 2018-Q2
2018-05-02 - Kvartalsrapport 2018-Q1
2018-03-23 - X-dag halvårsutdelning NOVO B 4.85
2018-03-22 - Årsstämma
2018-02-01 - Bokslutskommuniké 2017
2017-11-01 - Kvartalsrapport 2017-Q3
2017-08-18 - X-dag halvårsutdelning NOVO B 3
2017-08-09 - Kvartalsrapport 2017-Q2
2017-05-03 - Kvartalsrapport 2017-Q1
2017-03-24 - X-dag ordinarie utdelning NOVO B 4.60 DKK
2017-03-23 - Årsstämma
2017-02-02 - Bokslutskommuniké 2016
2016-10-28 - Kvartalsrapport 2016-Q3
2016-08-12 - X-dag halvårsutdelning NOVO B 3
2016-08-05 - Kvartalsrapport 2016-Q2
2016-04-29 - Kvartalsrapport 2016-Q1
2016-03-21 - X-dag halvårsutdelning NOVO B 6.4
2016-03-18 - Årsstämma
2016-02-03 - Bokslutskommuniké 2015
2015-10-29 - Kvartalsrapport 2015-Q3
2015-08-06 - Kvartalsrapport 2015-Q2
2015-04-30 - Kvartalsrapport 2015-Q1
2015-03-20 - X-dag ordinarie utdelning NOVO B 5.00 DKK
2015-03-19 - Årsstämma
2015-01-30 - Bokslutskommuniké 2014
2014-10-30 - Kvartalsrapport 2014-Q3
2014-08-07 - Kvartalsrapport 2014-Q2
2014-05-01 - Kvartalsrapport 2014-Q1
2014-03-21 - X-dag ordinarie utdelning NOVO B 4.50 DKK
2014-03-20 - Årsstämma
2014-02-03 - Bokslutskommuniké 2013
2014-01-02 - Split NOVO B 1:5
2013-10-31 - Kvartalsrapport 2013-Q3
2013-08-08 - Kvartalsrapport 2013-Q2
2013-05-01 - Kvartalsrapport 2013-Q1
2013-03-21 - X-dag ordinarie utdelning NOVO B 18.00 DKK
2013-03-20 - Årsstämma
2013-02-04 - Bokslutskommuniké 2012
2012-10-31 - Kvartalsrapport 2012-Q3
2012-08-09 - Kvartalsrapport 2012-Q2
2012-04-27 - Kvartalsrapport 2012-Q1
2012-03-22 - X-dag ordinarie utdelning NOVO B 14.00 DKK
2012-03-21 - Årsstämma
2012-02-02 - Bokslutskommuniké 2011
2011-10-27 - Kvartalsrapport 2011-Q3
2011-08-04 - Kvartalsrapport 2011-Q2
2011-04-28 - Kvartalsrapport 2011-Q1
2011-03-24 - X-dag ordinarie utdelning NOVO B 10.00 DKK
2011-03-23 - Årsstämma
2011-02-02 - Bokslutskommuniké 2010
2010-03-25 - X-dag ordinarie utdelning NOVO B 7.50 DKK
2007-12-03 - Split NOVO B 1:2
2001-04-04 - Split NOVO B 1:5
1997-01-02 - Split NOVO B 1:2

Beskrivning

LandDanmark
ListaLarge Cap Copenhagen
SektorHälsovård
IndustriLäkemedel & Handel
Novo Nordisk är en producent av insulin för diabetesbehandling. Utöver specialistkompetensen inom diabetes producerar bolaget läkemedel för hormonbehandling samt produkter för hemofili och blödningsrubbningar. Produkterna återfinns på en global marknad och säljs under separata varumärken. Bolaget grundades ursprungligen under 1923 och har sitt huvudkontor i Bagsværd, Danmark.
2024-09-20 14:43:15

Bagsværd, Denmark, 20 September 2024 – Novo Nordisk today announced headline results from a phase 2a clinical trial with monlunabant, a small molecule oral cannabinoid receptor 1 (CB1) inverse agonist. Monlunabant, formerly INV-202, was part of the acquisition of Inversago Pharmaceuticals Inc. announced in August 2023 [Link].

The trial investigated the efficacy and safety of a once-daily 10 mg, 20 mg and 50 mg dose of monlunabant compared to placebo on body weight after 16 weeks in 243 people with obesity and metabolic syndrome1. People were equally randomised among the four treatment arms.

From a baseline body weight of 110.1 kg, all doses of monlunabant achieved a statistically significant weight loss compared to placebo. After 16 weeks of treatment, people treated with a once-daily 10 mg dose of monlunabant achieved a weight loss of 7.1 kg compared to a reduction of 0.7 kg with placebo2. Limited additional weight loss was seen at higher doses of monlunabant.

In the trial, the most common adverse events were gastrointestinal, with the vast majority being mild to moderate and dose dependent. Reporting of mild to moderate neuropsychiatric side effects, primarily anxiety, irritability, and sleep disturbances, was more frequent and dose dependent with monlunabant compared to placebo. No serious adverse events were reported in relation to neuropsychiatric side effects.

“The phase 2a results indicate the weight-lowering potential of monlunabant and that further work is needed to determine the optimal dosing to balance safety and efficacy,” said Martin Holst Lange, executive vice president and head of Development at Novo Nordisk. “Obesity is a complex disease with a significant unmet need, and as an oral small molecule having a new mechanism of action, monlunabant is one of the novel projects in our pipeline with the potential of treating obesity.”

Based on the results, Novo Nordisk expects to initiate a larger phase 2b trial in obesity to further investigate dosing and the safety profile of monlunabant over a longer duration in a global population. The phase 2b trial is expected to be initiated in 2025.

About monlunabant and CB1
Monlunabant is an inverse agonist of the CB1 receptor which plays an important role in metabolism and appetite regulation in the central nervous system as well as in peripheral tissues such as adipose tissues, the gastrointestinal tract, kidneys, liver, pancreas, muscles and lungs. CB1 plays an important role in appetite regulation and cardiometabolic pathways.

About Novo Nordisk
Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases, built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 69,000 people in 80 countries and markets its products in around 170 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com, Facebook, Instagram, X, LinkedIn and YouTube.

Contacts for further information

Media: 
Ambre James-Brown
+45 3079 9289
abmo@novonordisk.com

Liz Skrbkova (US)
+1 609 917 0632
lzsk@novonordisk.com

Investors: 
Jacob Martin Wiborg Rode
+45 3075 5956
jrde@novonordisk.com

David Heiberg Landsted
+45 3077 6915
dhel@novonordisk.com

Sina Meyer
+45 3079 6656 azey@novonordisk.com

Ida Schaap Melvold
+45 3077 5649 idmg@novonordisk.com

Frederik Taylor Pitter (US)
+1 609 613 0568
fptr@novonordisk.com

Mark Joseph Root (US)
+1 848 213 3219
mjhr@novonordisk.com

 

Company announcement No 71 /2024


1 Metabolic syndrome defined as the presence of at least 3 of 5 key clinical features of abdominal obesity, elevated triglycerides and cholesterol, impaired glucose tolerance, and elevated blood pressure.
2 Hypothetical estimand corresponding to if all people adhered to treatment