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2024-11-06 Kvartalsrapport 2024-Q3
2024-08-07 Kvartalsrapport 2024-Q2
2024-05-02 Kvartalsrapport 2024-Q1
2024-03-22 X-dag halvårsutdelning NOVO B 6.4
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2023-11-02 Kvartalsrapport 2023-Q3
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2023-08-18 X-dag halvårsutdelning NOVO B 6
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2023-03-24 X-dag halvårsutdelning NOVO B 8.15
2023-03-23 Årsstämma 2023
2023-02-01 Bokslutskommuniké 2022
2022-11-02 Kvartalsrapport 2022-Q3
2022-08-12 X-dag halvårsutdelning NOVO B 4.25
2022-08-04 Kvartalsrapport 2022-Q2
2022-05-04 Kvartalsrapport 2022-Q1
2022-03-25 X-dag halvårsutdelning NOVO B 6.9
2022-03-24 Årsstämma 2022
2022-02-02 Bokslutskommuniké 2021
2021-11-03 Kvartalsrapport 2021-Q3
2021-08-16 X-dag halvårsutdelning NOVO B 3.5
2021-08-05 Kvartalsrapport 2021-Q2
2021-05-05 Kvartalsrapport 2021-Q1
2021-03-26 X-dag halvårsutdelning NOVO B 5.85
2021-03-25 Årsstämma 2021
2021-02-03 Bokslutskommuniké 2020
2020-10-30 Kvartalsrapport 2020-Q3
2020-08-14 X-dag halvårsutdelning NOVO B 3.25
2020-08-06 Kvartalsrapport 2020-Q2
2020-05-06 Kvartalsrapport 2020-Q1
2020-03-27 X-dag halvårsutdelning NOVO B 5.35
2020-03-26 Årsstämma 2020
2020-02-05 Bokslutskommuniké 2019
2019-11-01 Kvartalsrapport 2019-Q3
2019-08-21 Kvartalsrapport 2019-Q2
2019-08-16 X-dag halvårsutdelning NOVO B 3
2019-05-03 Kvartalsrapport 2019-Q1
2019-03-22 X-dag halvårsutdelning NOVO B 5.15
2019-03-21 Årsstämma 2019
2019-02-01 Bokslutskommuniké 2018
2018-08-18 X-dag halvårsutdelning NOVO B 3
2018-08-08 Kvartalsrapport 2018-Q2
2018-05-02 Kvartalsrapport 2018-Q1
2018-03-23 X-dag halvårsutdelning NOVO B 4.85
2018-03-22 Årsstämma 2018
2018-02-01 Bokslutskommuniké 2017
2017-11-01 Kvartalsrapport 2017-Q3
2017-08-18 X-dag halvårsutdelning NOVO B 3
2017-08-09 Kvartalsrapport 2017-Q2
2017-05-03 Kvartalsrapport 2017-Q1
2017-03-24 X-dag ordinarie utdelning NOVO B 4.60 DKK
2017-03-23 Årsstämma 2017
2017-02-02 Bokslutskommuniké 2016
2016-10-28 Kvartalsrapport 2016-Q3
2016-08-12 X-dag halvårsutdelning NOVO B 3
2016-08-05 Kvartalsrapport 2016-Q2
2016-04-29 Kvartalsrapport 2016-Q1
2016-03-21 X-dag halvårsutdelning NOVO B 6.4
2016-03-18 Årsstämma 2016
2016-02-03 Bokslutskommuniké 2015
2015-10-29 Kvartalsrapport 2015-Q3
2015-08-06 Kvartalsrapport 2015-Q2
2015-04-30 Kvartalsrapport 2015-Q1
2015-03-20 X-dag ordinarie utdelning NOVO B 5.00 DKK
2015-03-19 Årsstämma 2015
2015-01-30 Bokslutskommuniké 2014
2014-10-30 Kvartalsrapport 2014-Q3
2014-08-07 Kvartalsrapport 2014-Q2
2014-05-01 Kvartalsrapport 2014-Q1
2014-03-21 X-dag ordinarie utdelning NOVO B 4.50 DKK
2014-03-20 Årsstämma 2014
2014-02-03 Bokslutskommuniké 2013
2014-01-02 Split NOVO B 1:5
2013-10-31 Kvartalsrapport 2013-Q3
2013-08-08 Kvartalsrapport 2013-Q2
2013-05-01 Kvartalsrapport 2013-Q1
2013-03-21 X-dag ordinarie utdelning NOVO B 18.00 DKK
2013-03-20 Årsstämma 2013
2013-02-04 Bokslutskommuniké 2012
2012-10-31 Kvartalsrapport 2012-Q3
2012-08-09 Kvartalsrapport 2012-Q2
2012-04-27 Kvartalsrapport 2012-Q1
2012-03-22 X-dag ordinarie utdelning NOVO B 14.00 DKK
2012-03-21 Årsstämma 2012
2012-02-02 Bokslutskommuniké 2011
2011-10-27 Kvartalsrapport 2011-Q3
2011-08-04 Kvartalsrapport 2011-Q2
2011-04-28 Kvartalsrapport 2011-Q1
2011-03-24 X-dag ordinarie utdelning NOVO B 10.00 DKK
2011-03-23 Årsstämma 2011
2011-02-02 Bokslutskommuniké 2010
2010-03-25 X-dag ordinarie utdelning NOVO B 7.50 DKK
2007-12-03 Split NOVO B 1:2
2001-04-04 Split NOVO B 1:5
1997-01-02 Split NOVO B 1:2

Beskrivning

LandDanmark
ListaLarge Cap Copenhagen
SektorHälsovård
IndustriLäkemedel & Handel
Novo Nordisk är en producent av insulin för diabetesbehandling. Utöver specialistkompetensen inom diabetes producerar bolaget läkemedel för hormonbehandling samt produkter för hemofili och blödningsrubbningar. Produkterna återfinns på en global marknad och säljs under separata varumärken. Bolaget grundades ursprungligen under 1923 och har sitt huvudkontor i Bagsværd, Danmark.
2023-08-08 11:56:06

Bagsværd, Denmark, 8 August 2023 – Novo Nordisk today announced the headline results from the SELECT cardiovascular outcomes trial. The double-blinded trial compared subcutaneous once-weekly semaglutide 2.4 mg with placebo as an adjunct to standard of care for prevention of major adverse cardiovascular events (MACEs) over a period of up to five years. The trial enrolled 17,604 adults aged 45 years or older with overweight or obesity and established cardiovascular disease (CVD) with no prior history of diabetes.

The trial achieved its primary objective by demonstrating a statistically significant and superior reduction in MACE of 20% for people treated with semaglutide 2.4 mg compared to placebo1. The primary endpoint of the study was defined as the composite outcome of the first occurrence of MACE defined as cardiovascular death, non-fatal myocardial infarction or non-fatal stroke. All three components of the primary endpoint contributed to the superior MACE reduction demonstrated by semaglutide 2.4 mg. 1,270 first MACEs were accrued.

In the trial, semaglutide 2.4 mg appeared to have a safe and well-tolerated profile in line with previous semaglutide 2.4 mg trials.

"People living with obesity have an increased risk of cardiovascular disease but to date, there are no approved weight management medications proven to deliver effective weight management while also reducing the risk of heart attack, stroke or cardiovascular death. Therefore, we are very excited about the results from SELECT showing that semaglutide 2.4 mg reduces the risk of cardiovascular events,” said Martin Holst Lange, executive vice president for Development at Novo Nordisk. “SELECT is a landmark trial and has demonstrated that semaglutide 2.4 mg has the potential to change how obesity is regarded and treated.”

Novo Nordisk expects to file for regulatory approvals of a label indication expansion for semaglutide 2.4 mg (Wegovy®) in the US and the EU in 2023. The detailed results from SELECT will be presented at a scientific conference later in 2023.

About the SELECT trial
SELECT was a randomised, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of semaglutide 2.4 mg versus placebo as an adjunct to standard of care for prevention of MACE in people with established CVD with overweight or obesity with no prior history of diabetes. People included in the trial were aged ≥45 years with a BMI ≥27 kg/m2.

The primary objective of the SELECT trial was to demonstrate superiority of semaglutide 2.4 mg compared to placebo with respect to reducing the incidence of three-point MACE consisting of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke. Key secondary objectives were to compare the effects of semaglutide 2.4 mg to placebo with regards to mortality, cardiovascular risk factors, glucose metabolism, body weight and renal function.

The trial enrolled 17,604 adults and has been conducted in 41 countries at more than 800 investigator sites. The SELECT trial was initiated in 2018.

About Wegovy®
Wegovy® (once-weekly subcutaneous semaglutide 2.4 mg) is a GLP-1 receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with a BMI of 30 kg/m2 or greater (obesity), adults with a BMI of 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition, and pediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and gender (obesity). Wegovy® is launched in the US, Denmark, Norway and Germany.

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 57,100 people in 80 countries and markets its products in around 170 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com, Facebook, X (Twitter), LinkedIn and YouTube.

Contacts for further information

Media: 
Ambre James-Brown
+45 3079 9289
abmo@novonordisk.com

Natalia Salomao Abrahao (US)
+1 848 304 1027
niaa@novonordisk.com

Investors: 
Daniel Muusmann Bohsen
+45 3075 2175
dabo@novonordisk.com

Jacob Martin Wiborg Rode
+45 3075 5956
jrde@novonordisk.com

David Heiberg Landsted
+45 3077 6915
dhel@novonordisk.com

Mark Joseph Root (US)
+1 848 213 3219
mjhr@novonordisk.com

Sina Meyer
+45 3077 6656
azey@novonordisk.com

Frederik Taylor Pitter
+45 3075 8259
fptr@novonordisk.com

Company announcement No 50 / 2023


1 Based on treatment policy estimand: treatment effect regardless of treatment adherence